Comparative efficacy of quarterly vs. monthly triptorelin in Chinese girls with central precocious puberty: a 12-month observational study.

BACKGROUND

This study aimed to compare the clinical efficacy of quarterly (15 mg/90 days) versus monthly (3.75 mg/28 days) triptorelin formulations with respect to bone maturation, predicted adult height (PAH), and hormonal suppression in Chinese girls with central precocious puberty (CPP).

METHODS

This retrospective cohort study included 70 girls diagnosed with CPP at Fuzhou First General Hospital from March 2023 to 2025. Participants were assigned to either a quarterly regimen (triptorelin 15 mg every 90 days, n = 32) or a monthly regimen (triptorelin 3.75 mg every 28 days, n = 38). The evaluated outcomes included bone age (BA; TW3 method), PAH, serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) concentrations, uterine and ovarian volumes, body mass index (BMI), and adverse events, assessed at baseline, 6 months, and 12 months.

RESULTS

After 12 months of treatment, both regimens achieved effective and comparable suppression of LH (quarterly: 0.30 ± 0.19 IU/L; monthly: 0.30 ± 0.26 IU/L; both P < 0.001 vs. baseline) and FSH (quarterly:1.22 ± 0.91 IU/L; monthly: 1.31 ± 0.65 IU/L; P < 0.05 vs. baseline). Improvements in PAH were also comparable between groups (quarterly: 3.95 ± 2.97 cm; monthly: 2.91 ± 2.70 cm; P = 0.790). No significant between-group differences were observed in BA maturation, growth velocity, or uterine and ovarian volumes (P > 0.05). BMI increased significantly in both groups (quarterly: from 16.96 ± 2.10 to 17.89 ± 2.53 kg/m2, P = 0.01; monthly: from 16.89 ± 2.06 to 17.50 ± 2.03 kg/m2, P = 0.008), with no significant differences between regimens. Three patients experiencing a "flare-up" had a larger mean baseline uterine volume (6.95 mL) compared with the remaining 67 patients (2.38 mL).

CONCLUSION

Quarterly triptorelin demonstrated efficacy comparable to that of monthly administration in suppressing puberty and improving PAH in Chinese girls with CPP.