Archives of endocrinology and metabolism · 2025
Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Anunciação Sara Moreira, Campos Renata de Oliveira, Beltrão Fabyan Esberard de Lima, Morais Déborah Araújo, de Wellington Sousa Tavares, Barbosa Fernando, Cassemiro Jéssica Fernanda, Rende Pedro Resende Ferreira, Hecht Fabio, Ramos Helton Estrela
Аннотация
OBJECTIVE: This study aimed to assess urinary selenium concentration (USC) and its correlation with non-thyroidal illness syndrome (NTIS) and inflammatory markers in hospitalized adult patients with COVID-19.
SUBJECTS AND METHODS: A prospective study was conducted to investigate urinary selenium (Se) concentration in adult patients hospitalized with COVID-19 between June and August 2020. Urine and serum samples were collected before complications occurred, always within the first 48 hours after onset. A total of 121 patients were stratified into three tertiles based on USC: (i) USC < 25 μg/L (), (ii) USC 25-39 μg/L (), and (iii) USC > 39 μg/L (). ICP-MS was employed to measure urinary Se concentration. NTIS was defined by free triiodothyronine below 2.3 pg/L accompanied by low or normal thyroid-stimulating hormone levels.
RESULTS: NTIS was observed in a low prevalence (5.7%) and was significantly associated with patients having the lowest USC (n = 6, p = 0.008). Thyroiditis was the most prevalent thyroid complication (23.9%); however, there was no significant association with USC (p > 0.05).
CONCLUSION: The association between low USC and NTIS was evident in this cohort.
SUBJECTS AND METHODS: A prospective study was conducted to investigate urinary selenium (Se) concentration in adult patients hospitalized with COVID-19 between June and August 2020. Urine and serum samples were collected before complications occurred, always within the first 48 hours after onset. A total of 121 patients were stratified into three tertiles based on USC: (i) USC < 25 μg/L (), (ii) USC 25-39 μg/L (), and (iii) USC > 39 μg/L (). ICP-MS was employed to measure urinary Se concentration. NTIS was defined by free triiodothyronine below 2.3 pg/L accompanied by low or normal thyroid-stimulating hormone levels.
RESULTS: NTIS was observed in a low prevalence (5.7%) and was significantly associated with patients having the lowest USC (n = 6, p = 0.008). Thyroiditis was the most prevalent thyroid complication (23.9%); however, there was no significant association with USC (p > 0.05).
CONCLUSION: The association between low USC and NTIS was evident in this cohort.