European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025
Association of asparagine in saliva with a lower risk of early childhood caries in undernourished children: a cross-sectional study.
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Lima P H M, Mota A C M, Lima V, Cidrao G P, Toyama D O, Toyama M H, Fonteles C S
Аннотация
AIM: The aim was to investigate the salivary amino acid profile in children with protein-energy undernutrition (PEU) and its association with caries experience in the presence of other risk factors.
METHODS: The study had a cross-sectional design and was carried out with 122 children (12-71 months old), classified according to their level of undernutrition (mild-GI, n = 22; moderate-GII, n = 53) or healthy controls (GC, n = 47). The children were categorized based on the presence of caries into caries-experienced groups (ceos > 0, 22 CG, 12 GI and 18 GII) and caries-free groups (ceos = 0, 25 CG, 10 GI and 36 GII). Total unstimulated and stimulated saliva were collected to determine amino acids and Streptococcus mutans, respectively.
RESULTS: Eighteen amino acids were associated with PEU. Undernutrition and caries experience influenced the presence of the following amino acids: L-anserine, asparagine, ethanolamine, gamma-aminobutyric acid, and norleucine. Asparagine was a significant predictor of a lower probability of caries experience in a logistic regression model.
CONCLUSIONS: Salivary amino acids are associated with undernutrition in children, and the presence of asparagine in saliva relates to a lower caries risk.
METHODS: The study had a cross-sectional design and was carried out with 122 children (12-71 months old), classified according to their level of undernutrition (mild-GI, n = 22; moderate-GII, n = 53) or healthy controls (GC, n = 47). The children were categorized based on the presence of caries into caries-experienced groups (ceos > 0, 22 CG, 12 GI and 18 GII) and caries-free groups (ceos = 0, 25 CG, 10 GI and 36 GII). Total unstimulated and stimulated saliva were collected to determine amino acids and Streptococcus mutans, respectively.
RESULTS: Eighteen amino acids were associated with PEU. Undernutrition and caries experience influenced the presence of the following amino acids: L-anserine, asparagine, ethanolamine, gamma-aminobutyric acid, and norleucine. Asparagine was a significant predictor of a lower probability of caries experience in a logistic regression model.
CONCLUSIONS: Salivary amino acids are associated with undernutrition in children, and the presence of asparagine in saliva relates to a lower caries risk.