Annals of surgical oncology · 2026
Patterns of Recurrence in Adenocarcinoma of the Esophagogastric Junction: ERECS Trial Post Hoc Analysis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
de Pascale Stefano, Rosati Riccardo, Bagnardi Vincenzo, De Pasqual Carlo Alberto, Ferrari Giovanni, Frassoni Samuele, Giacopuzzi Simone, Gualtierotti Monica, Leone Nicola, Moletta Lucia, Pallabazzer Giovanni, Puccetti Francesco, Realis Luc Marco, Rebecchi Fabrizio, Santi Stefano, Valmasoni Michele, Fumagalli Romario Uberto, SISME–Società Italiana per lo Studio delle Malattie dell’Esofago–Italian Society of Disease of the Esophagus
Аннотация
BACKGROUND: Adenocarcinoma of the esophagogastric junction (AEG) is associated with high recurrence rates despite multimodal therapy. Understanding recurrence patterns and their predictive factors is critical for optimizing risk stratification and guiding therapeutic decision-making.
METHODS: This post hoc analysis of the multicenter retrospective ERECS trial included patients who had Siewert type 1 or 2 AEG treated with perioperative chemotherapy (BMT) or neoadjuvant chemoradiotherapy (TMT) followed by Ivor Lewis esophagectomy between January 2018 and December 2022. Uni- and multivariable Fine and Gray regression models identified predictors of recurrence. Overall survival after recurrence (OSAR) was estimated using the Kaplan-Meier method.
RESULTS: Of 455 patients, 7.9% experienced local recurrence (LR) and 36.9% had distant recurrence (DR) during a median follow-up period of 29.8 months. Among the DR patients, 56% had single-site (sDR) and 44% multiple-site (mDR) involvement. Lymph nodes, liver, and lungs were the most frequently involved distant sites. In the multivariable analysis, TMT and mucinous histology independently predicted LR, whereas advanced pathologic stage, poor response to neoadjuvant therapy, and perineural invasion were associated with DR. For sDR, OSAR was better than mDR (12-month OSAR: 62% vs. 42%; p = 0.037).
CONCLUSIONS: Distant recurrence remains the principal driver of treatment failure in locally advanced AEG. Advanced pathologic stage, poor treatment response, and perineural invasion identify patients at high systemic risk who may benefit from intensified systemic therapy. In this study, post-recurrence survival was significantly better for sDR (which does not fully correspond to oligometastatic disease) than for mDR. Prospective validation of a tailored surveillance strategy for high-risk patients is warranted.
METHODS: This post hoc analysis of the multicenter retrospective ERECS trial included patients who had Siewert type 1 or 2 AEG treated with perioperative chemotherapy (BMT) or neoadjuvant chemoradiotherapy (TMT) followed by Ivor Lewis esophagectomy between January 2018 and December 2022. Uni- and multivariable Fine and Gray regression models identified predictors of recurrence. Overall survival after recurrence (OSAR) was estimated using the Kaplan-Meier method.
RESULTS: Of 455 patients, 7.9% experienced local recurrence (LR) and 36.9% had distant recurrence (DR) during a median follow-up period of 29.8 months. Among the DR patients, 56% had single-site (sDR) and 44% multiple-site (mDR) involvement. Lymph nodes, liver, and lungs were the most frequently involved distant sites. In the multivariable analysis, TMT and mucinous histology independently predicted LR, whereas advanced pathologic stage, poor response to neoadjuvant therapy, and perineural invasion were associated with DR. For sDR, OSAR was better than mDR (12-month OSAR: 62% vs. 42%; p = 0.037).
CONCLUSIONS: Distant recurrence remains the principal driver of treatment failure in locally advanced AEG. Advanced pathologic stage, poor treatment response, and perineural invasion identify patients at high systemic risk who may benefit from intensified systemic therapy. In this study, post-recurrence survival was significantly better for sDR (which does not fully correspond to oligometastatic disease) than for mDR. Prospective validation of a tailored surveillance strategy for high-risk patients is warranted.