Journal of psychosomatic research · 2026
Distinct neural substrates of affective distress and communicative disability in head and neck cancer: A cross-sectional 18F-FDG PET study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tsionis Antonis, Kyrodimos Efthymios, Chatziioannou Sofia, Papageorgiou Charalambos
Аннотация
BACKGROUND: Head and neck cancer (HNC) threatens communication through its impact on voice and speech. The neural systems linking depressive symptoms with perceived voice handicap remain poorly characterized. We examined whether these symptom domains show dissociable associations with regional brain metabolism.
METHODS: In this cross-sectional 18F-FDG PET, we studied 63 HNC patients following diagnosis. Regional glucose metabolism (standardized uptake value ratios) was quantified in a priori regions of interest: Broca's area, Wernicke's area, left and right insula, and bilateral hippocampus. Depressive symptoms (Zung Self-Rating Depression Scale) and perceived voice handicap (Voice Handicap Index) were assessed. Spearman correlations with false discovery rate correction, partial correlations, and unique variance analyses were performed.
RESULTS: Depression and voice handicap were strongly correlated (ρ = 0.64, p < 0.001) and exhibited partially dissociable metabolic correlates. Depressive symptoms were associated with reduced metabolism in Broca's area (ρ = -0.33, pFDR = 0.041) and higher metabolism in the left insula (ρ = 0.36, pFDR = 0.039), with graded insular elevation in moderate-severe depression (+12.5%, p = 0.008). These associations remained significant after age/sex adjustment and nominally significant after tumor-site adjustment. In exploratory analyses, voice handicap showed a negative association with hippocampal metabolism that did not survive FDR (ρ = -0.28, pFDR = 0.137) but reached significance after covariate adjustment (ρ = -0.34, p = 0.016).
CONCLUSIONS: Depression and voice handicap in HNC show partially dissociable associations with regional brain metabolism despite clinical co-occurrence. Routine clinical imaging may be leveraged to generate hypotheses for psychosomatic and rehabilitation research.
METHODS: In this cross-sectional 18F-FDG PET, we studied 63 HNC patients following diagnosis. Regional glucose metabolism (standardized uptake value ratios) was quantified in a priori regions of interest: Broca's area, Wernicke's area, left and right insula, and bilateral hippocampus. Depressive symptoms (Zung Self-Rating Depression Scale) and perceived voice handicap (Voice Handicap Index) were assessed. Spearman correlations with false discovery rate correction, partial correlations, and unique variance analyses were performed.
RESULTS: Depression and voice handicap were strongly correlated (ρ = 0.64, p < 0.001) and exhibited partially dissociable metabolic correlates. Depressive symptoms were associated with reduced metabolism in Broca's area (ρ = -0.33, pFDR = 0.041) and higher metabolism in the left insula (ρ = 0.36, pFDR = 0.039), with graded insular elevation in moderate-severe depression (+12.5%, p = 0.008). These associations remained significant after age/sex adjustment and nominally significant after tumor-site adjustment. In exploratory analyses, voice handicap showed a negative association with hippocampal metabolism that did not survive FDR (ρ = -0.28, pFDR = 0.137) but reached significance after covariate adjustment (ρ = -0.34, p = 0.016).
CONCLUSIONS: Depression and voice handicap in HNC show partially dissociable associations with regional brain metabolism despite clinical co-occurrence. Routine clinical imaging may be leveraged to generate hypotheses for psychosomatic and rehabilitation research.