Klinische Monatsblatter fur Augenheilkunde · 1993
[Ocular complications of long-term survival of bone marrow transplantation. A prospective study with 21 patients].
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Bautista Juanes J A, Theischen M, Beelen D W, Pauleikhoff D, Koch J M, Waubke T N, Wessing A
Аннотация
BACKGROUND: Survival time after bone marrow transplantation is getting increasingly longer and secondary ocular complications need to be identified and deserve more attention as so far.
PATIENTS AND METHODS: We evaluated the ocular complications of 21 not selected, long-term survivors after bone marrow transplantation in a prospective study. The ophthalmological examination consisted of visual acuity, slit lamp examination, tonometry and ophthalmoscopy. It included also determination of tears break-up-time, Jones-test, rose bengal staining and impression cytology of the conjunctiva.
RESULTS: The major ocular complication was the development of a keratoconjunctivitis sicca syndrome in 14 of the 21 patients. This complication is probably due to the total-body irradiation in the preparative before and to the development of a chronic Graft-versus-Host-Disease after transplantation. 13 of the 21 patients developed a cataract. This might be a result of the total-body irradiation and a prolonged high steroid intake.
CONCLUSION: The frequency and severity of ocular complications suggest that detailed ocular examinations should be performed routinely in patients after bone marrow transplantation.
PATIENTS AND METHODS: We evaluated the ocular complications of 21 not selected, long-term survivors after bone marrow transplantation in a prospective study. The ophthalmological examination consisted of visual acuity, slit lamp examination, tonometry and ophthalmoscopy. It included also determination of tears break-up-time, Jones-test, rose bengal staining and impression cytology of the conjunctiva.
RESULTS: The major ocular complication was the development of a keratoconjunctivitis sicca syndrome in 14 of the 21 patients. This complication is probably due to the total-body irradiation in the preparative before and to the development of a chronic Graft-versus-Host-Disease after transplantation. 13 of the 21 patients developed a cataract. This might be a result of the total-body irradiation and a prolonged high steroid intake.
CONCLUSION: The frequency and severity of ocular complications suggest that detailed ocular examinations should be performed routinely in patients after bone marrow transplantation.
Предметные рубрики MeSH
Anemia, AplasticBone Marrow TransplantationCataractFollow-Up StudiesGraft vs Host DiseaseHumansImmunosuppression TherapyKeratoconjunctivitis SiccaLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteOphthalmoscopyPrecursor Cell Lymphoblastic Leukemia-LymphomaProspective StudiesVisual Acuity