Triamcinolone acetate and triamcinolone-isotretinoin efficacy in oral lichen planus management: Original clinical study.

Oral lichen planus (OLP) is a long-term inflammatory mucocutaneous disease that has the potential of malignant transformation. Hence, it requires effective long-term therapy. It was a randomized controlled, double-blind trial comparing triamcinolone acetonide 0.1 per cent oral paste (TA) to TA once daily with oral isotretinoin 10mg daily (TA+ISO) in 70 cases (biopsy-established) of OLP of more than 12 weeks duration. The TA+ISO group showed better clinical outcomes as the means of Thongprasom scores reduced in the TA group (p<0.001). TA+ISO showed more pain reduction (VAS) at 12 weeks (p<0.001), improved Histopathological (74.3) TA+ISO (p=0.006) and reduced Lesion size (p<0.001). TA in combination with isotretinoin is very useful as combination therapy in OLP and clinical and histopathological results are improved.