Sixteen years experience in six cases of Conn syndrome in Jakarta.

Primary hyperaldosteronism or Conn syndrome is the syndrome formed from the triad of hypertension, hypokalemia, and metabolic alkalosis. Six patients of Conn syndrome, two females (21 and 50 years) and 4 males (30, 33, 46, dan 51 years), were reported. All of the cases came with the symptoms of weakness of the lower extremities in conjunction with hypertension. The plasma aldosterone level was high with the very low plasma renin activity in all of the cases. All of the patients in this case had metabolic alkalosis. Unilateral adrenal mass was found on CT-Scan or MRI imaging. Following adrenalectomy, three patients (one female and two males) still needed one type of anti hypertension drug. All of the patients did not require anti aldosterone anymore. The plasma aldosterone returned to normal value in three patients while in three other patients were not checked. The histopathology of the adrenal revealed the adenoma of the adrenal cortex in all of the six cases.