Clozapine for Post-traumatic Stress Disorder: Redefining Treatment Resistance in Soldiers without Psychosis.

Post-traumatic stress disorder (PTSD) often follows a chronic trajectory, with many patients failing to respond to first-line psychotherapy and SSRIs/SNRIs. This case series explores clozapine for treatment-resistant PTSD (TR-PTSD) without psychosis. Seven soldiers showed improved function and reduced aggression at doses of 125-300 mg, suggesting that clozapine warrants further investigation.