Computer methods in biomechanics and biomedical engineering · 2026
Identifying therapeutic target genes for acute pancreatitis based on the druggable genes.
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Cao Kejun, Cheng Qiang, Zhu Jun, Wang Bing
Аннотация
To screen therapeutic target genes for AP, MR analysis was conducted, followed by DEG screening, nomogram, GSEA, drug prediction, and molecular docking analyses.529 druggable genes were obtained. After intersection, 36 overlapping genes were identified. Eight overlapping feature genes were screened after PPI and machine learning. Among them, four therapeutic target genes were screened as therapeutic target genes, containing ACVR1C, RASGRP1, RPTOR, and SPTBN1. These four genes are mainly involved in primary immunodeficiency, and both are negatively associated with activated dendritic cells, neutrophils, and macrophages. Molecular docking analysis highlighted the affinity of the four therapeutic target genes for glucose.