Current medicinal chemistry · 2023
Cinnamaldehyde for the Treatment of Microbial Infections: Evidence Obtained from Experimental Models.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Silva E Silva Figueiredo Cristiane Santos, de Oliveira Patrícia Vieira, Dos Reis Ferreira Larissa, de Sousa Thallysson José Dourado, de Santana do Nascimento Mayara, Dos Santos Julliana Ribeiro Alves, Zagmignan Adrielle, de Holanda Rodrigo Assunção, de Carvalho Galvão Lívia Câmara, da Silva Luís Cláudio Nascimento
Аннотация
Cinnamaldehyde (CNM) is a cyclic terpene alcohol found as the major compound of essential oils from some plants of the genus Cinnamomum (Lauraceae). CNM has several reported pharmacological activities, including antimicrobial, antivirulence, antioxidant, and immunomodulatory effects. These properties make CNM an attractive lead molecule for the development of anti-infective agents. In this descriptive review, we discuss the application of CNM in experimental models of microbial infection using invertebrate and vertebrate organisms. CNM (pure or in formulations) has been successfully applied in the treatment of infections caused by a range of bacterial (such as Cronobacter sakazakii, Escherichia coli, Listeria monocytogenes, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Salmonella enterica, Staphylococcus aureus, Streptococcus agalactiae, Vibrio cholerae) and fungal (such as Aspergillus fumigatus, Candida albicans and Cryptococcus neoformans) pathogens. All these experimental evidence-based findings have promoted the use of cinnamaldehyde as the leading molecule for developing new anti- infective drugs.