Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
Psychiatric Disorders Before and After Inflammatory Bowel Disease Diagnosis: A Nationwide Cohort Study in Sweden 2007 to 2023.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sun Jiangwei, Li Lin, Chang Zheng, Butwicka Agnieszka, Bergman David, Sun Shihua, Marxer Carole A, Halfvarson Jonas, Olén Ola, Ludvigsson Jonas F
Аннотация
BACKGROUND & AIMS: Evidence suggests that patients with inflammatory bowel disease are at higher risk of psychiatric disorders, yet temporal pattern of risk elevation before/after inflammatory bowel disease diagnosis and role of familial factors remain unclear.
METHODS: Swedish patients with inflammatory bowel disease diagnosed between 2007 and 2023 were compared with reference individuals in a matched population-based cohort and compared with inflammatory bowel disease-free full siblings in a sibling-controlled cohort. Primary outcome was any psychiatric disorder, whereas secondary outcomes included psychotic disorders, mood disorders, anxiety disorders, eating disorders, substance misuse, personality disorders, attention-deficit/hyperactivity disorder, and autism spectrum disorders. We estimated temporal patterns of hazard ratios from 5 years before to 10 years after inflammatory bowel disease diagnosis by using flexible parametric survival models.
RESULTS: The study included 43,862 patients with inflammatory bowel disease (mean age at diagnosis, 41.6 years; 47.3% female) and 178,821 reference individuals. The hazard ratio of any psychiatric disorder started to increase from 2 to 3 years before inflammatory bowel disease diagnosis (eg, hazard ratio, 1.15; 95% confidence interval, 1.09-1.21 at -2 years), peaked immediately after inflammatory bowel disease diagnosis (hazard ratio, 1.50; 95% confidence interval, 1.41-1.59 at 0.5 year), and decreased rapidly thereafter but remained increased even at 10 years after diagnosis (hazard ratio, 1.19; 95% confidence interval, 1.13-1.24). The increased hazard ratio was mainly driven by major depressive disorder, anxiety disorders, and substance misuse. No increase was observed for psychotic disorders, personality disorders, and attention-deficit/hyperactivity disorder, although patients with inflammatory bowel disease were more likely to have autism spectrum disorders shortly after diagnosis and eating disorders from ≥5 years onwards. Similar temporal hazard ratio patterns were observed across all subtypes of inflammatory bowel disease: Crohn's disease, ulcerative colitis, and inflammatory bowel disease-unclassified. Similar risk increases for psychiatric disorders were observed in the sibling-controlled cohort.
CONCLUSIONS: Patients with inflammatory bowel disease were at an increased risk of several psychiatric disorders from 2 to 3 years before diagnosis through up to 10 years after, and this risk increase cannot be fully explained by shared familial factors.
METHODS: Swedish patients with inflammatory bowel disease diagnosed between 2007 and 2023 were compared with reference individuals in a matched population-based cohort and compared with inflammatory bowel disease-free full siblings in a sibling-controlled cohort. Primary outcome was any psychiatric disorder, whereas secondary outcomes included psychotic disorders, mood disorders, anxiety disorders, eating disorders, substance misuse, personality disorders, attention-deficit/hyperactivity disorder, and autism spectrum disorders. We estimated temporal patterns of hazard ratios from 5 years before to 10 years after inflammatory bowel disease diagnosis by using flexible parametric survival models.
RESULTS: The study included 43,862 patients with inflammatory bowel disease (mean age at diagnosis, 41.6 years; 47.3% female) and 178,821 reference individuals. The hazard ratio of any psychiatric disorder started to increase from 2 to 3 years before inflammatory bowel disease diagnosis (eg, hazard ratio, 1.15; 95% confidence interval, 1.09-1.21 at -2 years), peaked immediately after inflammatory bowel disease diagnosis (hazard ratio, 1.50; 95% confidence interval, 1.41-1.59 at 0.5 year), and decreased rapidly thereafter but remained increased even at 10 years after diagnosis (hazard ratio, 1.19; 95% confidence interval, 1.13-1.24). The increased hazard ratio was mainly driven by major depressive disorder, anxiety disorders, and substance misuse. No increase was observed for psychotic disorders, personality disorders, and attention-deficit/hyperactivity disorder, although patients with inflammatory bowel disease were more likely to have autism spectrum disorders shortly after diagnosis and eating disorders from ≥5 years onwards. Similar temporal hazard ratio patterns were observed across all subtypes of inflammatory bowel disease: Crohn's disease, ulcerative colitis, and inflammatory bowel disease-unclassified. Similar risk increases for psychiatric disorders were observed in the sibling-controlled cohort.
CONCLUSIONS: Patients with inflammatory bowel disease were at an increased risk of several psychiatric disorders from 2 to 3 years before diagnosis through up to 10 years after, and this risk increase cannot be fully explained by shared familial factors.