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DOI 10.1002/alz.14312

Медицинская библиотека · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024

Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research.

Nuytemans Karen, Franzen Sanne, Broce Iris J, Caramelli Paulo, Ellajosyula Ratnavalli, Finger Elizabeth, Gupta Veer, Gupta Vivek, Illán-Gala Ignacio, Loi Samantha M, Morhardt Darby, Pijnenburg Yolande, Rascovsky Katya, Williams Monique M, Yokoyama Jennifer S, Acosta-Uribe Juliana, Akinyemi Rufus, Alladi Suvarna, Ayele Biniyam A, Ayhan Yavuz, Bourdage Renelle, Castro-Suarez Sheila, de Souza Leonardo Cruz, Dacks Penny, de Boer Sterre C M, de Leon Jessica, Dodge Shana, Grasso Stephanie, Ghoshal Nupur, Kamath Vidyulata, Kumfor Fiona, Matias-Guiu Jordi A, Narme Pauline, Nielsen T Rune, Okhuevbie Daniel, Piña-Escudero Stefanie, Ruiz-Garcia Ramiro, Ryan Brigid, Scarioni Marta, Slachevsky Andrea, Suarez-Gonzalez Aida, Tee Boon Lead, Tsoy Elena, Ulugut Hulya, Onyike Chiadi U, Babulal Ganesh M, ISTAART Frontotemporal Dementia and Related Disorders PIA, ISTAART Diversity and Disparities PIA

СтатьяОбзорПоддержка правительства СШАПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Frontotemporal dementia (FTD) is one of the leading causes of young-onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure. This perspective paper was produced by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) and discusses the field's current status on the cross-cultural aspects of basic and translational research in FTD (including that focused on epidemiology, genetics, biomarkers, and treatment). It subsequently provides a summary of gaps and needs to address the disparities and advance global FTD biomedical research.

Для цитирования: Nuytemans Karen, Franzen Sanne, Broce Iris J, Caramelli Paulo, Ellajosyula Ratnavalli, Finger Elizabeth, Gupta Veer, Gupta Vivek, Illán-Gala Ignacio, Loi Samantha M, Morhardt Darby, Pijnenburg Yolande, Rascovsky Katya, Williams Monique M, Yokoyama Jennifer S, Acosta-Uribe Juliana, Akinyemi Rufus, Alladi Suvarna, Ayele Biniyam A, Ayhan Yavuz, Bourdage Renelle, Castro-Suarez Sheila, de Souza Leonardo Cruz, Dacks Penny, de Boer Sterre C M, de Leon Jessica, Dodge Shana, Grasso Stephanie, Ghoshal Nupur, Kamath Vidyulata, Kumfor Fiona, Matias-Guiu Jordi A, Narme Pauline, Nielsen T Rune, Okhuevbie Daniel, Piña-Escudero Stefanie, Ruiz-Garcia Ramiro, Ryan Brigid, Scarioni Marta, Slachevsky Andrea, Suarez-Gonzalez Aida, Tee Boon Lead, Tsoy Elena, Ulugut Hulya, Onyike Chiadi U, Babulal Ganesh M, ISTAART Frontotemporal Dementia and Related Disorders PIA, ISTAART Diversity and Disparities PIA. Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024. DOI: 10.1002/alz.14312.

Предметные рубрики MeSH

HumansBiomedical ResearchCultural DiversityFrontotemporal DementiaHealthcare Disparities
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