Endocrine-liver bidirectional regulation: From mechanistic research to multidisciplinary clinical practice.

A close bidirectional regulatory network exists between endocrine disorders and liver dysfunction, and their reciprocal imbalance is a key driver of metabolic liver diseases and chronic liver diseases. Based on the review, this letter systematically appraises its value in elucidating bidirectional crosstalk mechanisms across the thyroid, parathyroid, pancreas, adrenal, and sex hormone axes with the liver, while identifying limitations in mechanistic depth and clinical translation. Aligned with current clinical needs and research hotspots, we propose targeted research directions, including strengthening multi-omics biomarker screening, optimizing individualized management for special populations, and refining interdisciplinary collaboration, so as to provide comprehensive theoretical support and practical references for multidisciplinary team diagnosis and treatment of endocrine-related liver diseases.