[Early identification of a clustered epidemic of typhoid fever through pathogen molecular subtyping monitoring].

Objective

To identify a suspected clustered Typhoid fever by whole genome sequencing(WGS) and pulsed field gel electrophoresis (PFGE) subtyping.

Methods

The nature of the epidemic was determined by combination of subtyping results of isolates and epidemiological information.

Results

Five S. typhimurium isolates showed identical PFGE patterns and almost the same whole genome sequence. Epidemiological survey showed that five cases had dined in the same restaurant on the same day.

Conclusion

Combined with the longest incubation period of typhoid fever, molecular subtyping of pathogenic bacteria and the field epidemiological survey, it can be preliminarily determined that the five cases have common infection sources.