Epidemiology of concurrent extrapulmonary tuberculosis in inpatients with extrapulmonary tuberculosis lesions in China: a large-scale observational multi-centre investigation.
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Kang Wanli, Liu Shengsheng, Du Jian, Tang Peijun, Chen Hongyan, Liu Jianxiong, Ma Jinshan, Li Mingwu, Qin Jingmin, Shu Wei, Zong Peilan, Zhang Yi, Dong Yongkang, Yang Zhiyi, Mei Zaoxian, Deng Qunyi, Wang Pu, Han Wenge, Yan Xiaofeng, Chen Ling, Zhao Xinguo, Tan Lei, Li Fujian, Zheng Chao, Liu Hongwei, Li Xinjie, A Ertai, Du Yingrong, Liu Fenglin, Cui Wenyu, Wang Quanhong, Chen Xiaohong, Han Junfeng, Xie Qingyao, Feng Yanmei, Liu Wenyu, Yang Song, Zhang Jianyong, Zheng Jian, Chen Dawei, Yao Xiangyang, Ren Tong, Li Yan, Li Yuanyuan, Wu Lei, Song Qiang, Shen Xinghua, Zhang Jian, Liu Yuanyuan, Guo Shuliang, Yan Kun, Yang Mei, Lei Dan, Zhang Yanli, Wu Meiying, Li Liang, Tang Shenjie
Аннотация
METHODS: An observational multi-centre study of 208,214 patients with EPTB lesions was undertaken in China from January 2011 to December 2017. Multi-variable logistic regression analysis was used to identify associations between gender and concurrent EPTB, and age and concurrent EPTB. Association rules were analysed for significance using the Apriori algorithm.
RESULTS: The most common EPTB lesion was tuberculous pleurisy (49.8%), followed by bronchial TB (14.8%) and tuberculous meningitis (7.6%). The most common type of concurrent EPTB was tuberculous pleurisy concurrent with tuberculous peritonitis (1.80%). In total, 22 association rules, including 20 strong association rules, were identified; among these, the highest confidence rates were found for tuberculous myelitis concurrent with tuberculous meningitis, and sacral TB concurrent with lumbar vertebral TB. The association rules of EPTB concurrent with other EPTB types were found to vary with gender and age. The confidence rate of tuberculous myelitis concurrent with tuberculous meningitis was higher in females (83.67%) than males, and was highest in patients aged 25-34 years (87.50%).
CONCLUSIONS: Many types of concurrent EPTB were found. Greater awareness of concurrent EPTB disease characteristics is needed to ensure timely clinical diagnosis and treatment of this disease.