Evaluation of plasma Alpha klotho levels in obese cases.

BACKGROUND

Klotho is an anti-ageing gene that extends lifespan when overexpressed and accelerates ageing when disrupted. In our study, we will investigate the correlations between plasma <span style="color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);">α</span>-Klotho (<span style="color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);">α</span>-KL) protein levels with body mass index (BMI), carotid intima media thickness (CIMT), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), high-sensitivity C-reactive protein (hsCRP) and cholesterol values in obese patients.

METHODS

This study was conducted as a single-centre, cross-sectional study.

RESULTS

The study included 90 participants: 35 women (38.9%) and 55 men (61.1%). Of the participants included in the study, 30 were normal weight (33.3%) (Group 1), 30 were overweight (33.3%) (Group 2), and 30 were obese (33.3%) (Group 3). There were statistically significant differences in the <span style="color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);">α</span>-KL protein (p = 0.010), hsCRP (p&lt; 0.001), and homeostasis model assessment of insulin resistance (HOMA-IR) (p = 0.022) between the study groups. There is no significant difference between the study groups for CIMT (p= 0.380), TOS (p= 0.613), TAS (p= 0.056), or OSI (p= 0.943).

CONCLUSIONS

In this study, the overweight group had a-KL protein levels that were significantly higher than those in the obese group, whereas hsCRP levels were significantly higher in the obese group than in the overweight and normal weight groups. There were no significant differences in CIMT, TAS, TOS, and OSI values between the study groups. There were no significant correlations between <span style="color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);">α</span>-KL protein values and BMI, hsCRP CIMT, TAS, TOS, or OSI in participants in the study.