Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines-2024-2025 Revision: Part II-Guidelines on Oral and Ocular Treatments.
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Vieira Rafael José, Sousa-Pinto Bernardo, Bousquet Jean, Schünemann Holger J, Zuberbier Torsten, Bognanni Antonio, Togias Alkis, Samolinski Boleslaw, Valiulis Arunas, Williams Sian, Bedbrook Anna, Czarlewski Wienczyslawa, Torres Maria Jose, Shamji Mohamed H, Morais-Almeida Mário, Canonica G Walter, Vecillas Leticia de Las, Dykewicz Mark S, Jacomelli Cristina, Klimek Ludger, Leemann Lucas, Lourenço Olga, Papadopoulos Nikolaos G, Pereira Ana Margarida, Savouré Marine, Toppila-Salmi Sanna K, Ventura Maria Teresa, Yepes-Nuñez Juan José, Cruz Alvaro A, Ciprandi Giorgio, Gemicioglu Bilun, Giovannini Mattia, Gradauskiene Brigita, Jartti Tuomas, Jeseňák Miloš, Kuna Piotr, Kvedariene Violeta, Larenas-Linnemann Désirée E, Latiff Amir H A, Mohammad Yousser, Ohta Ken, Mahesh Padukudru A, Pali-Schöll Isabella, Pfaar Oliver, Regateiro Frederico S, Roche Nicolas, Taborda-Barata Luís, Ulrik Charlotte Suppli, Viegi Giovanni, Zhang Luo, Haahtela Tari, Cherrez-Ojeda Ivan, Ivancevich Juan Carlos, Khaltaev Nikolai, Yorgancioglu Arzu, Abdullah Baharudin, Al-Ahmad Mona, Al-Nesf Maryam Ali, Amaral Rita, Asllani Julijana, Bergmann Karl-C, Bernstein Jonathan A, Blaiss Michael S, Toskala Elina, Carreiro-Martins Pedro, Casale Thomas, Cecchi Lorenzo, Fiocchi Alessandro, Giuliano Antonio F M, Christoff George, Cirule Ieva, de Sousa Jaime Correia, Costa Elisio M, Devillier Philippe, Hossny Elham, Iinuma Tomohisa, Ispayeva Zhanat, Julge Kaja, Kaidashev Igor, Bennoor Kazi S, Kraxner Helga, Kull Inger, Kulus Marek, Kupczyk Maciej, Kurchenko Andriy, La Grutta Stefania, Miculinic Neven, Tuyet Lan Le Thi, Lee Sang Min, Montefort Stephen, Moreira Andre, Mullol Joaquim, Nadif Rachel, Nakonechna Alla, Neffen Hugo E, Niedoszytko Marek, O'Hehir Robyn E, Ogulur Ismail, Okamoto Yoshitaka, Olze Heidi, Palomares Oscar, Panzner Petr, Patella Vincenzo, Pitsios Constantinos, Puggioni Francesca, Quirce Santiago, Ramonaité Agné, Repka-Ramirez Maria Susana, Roberts Graham, Robles-Velasco Karla, Rottem Menachem, Salapatas Marianella, Sastre Joaquin, Scichilone Nicola, Sisul Juan-Carlos, Solé Dirceu, Soto-Martinez Manuel E, Sova Milan, Tantilipikorn Pongsakorn, Todo-Bom Ana, Tsaryk Vladyslav, Tsiligianni Ioanna, Urrutia-Pereira Marilyn, Valovirta Erkka, Vasankari Tuula, Wallace Dana, Wang De Yun, Worm Margitta, Yusuf Osman M, Gil-Mata Sara, Marques-Cruz Manuel, Mahboub Bassam, Romano Antonino, Aberer Werner, Artesani Maria Cristina, Azzolini Elena, Barreto Bruno, Bartra Joan, Becker Sven, Beghe Bianca, Boner Attilio, Borowiack Ewa, Bouchard Jacques, Brussino Luisa, Buhl Roland, Catamerò Francesco, Charpin Denis, Chavannes Niels H, Chełmińska Marta, Cheng Lei, Chkhartishvili Ekaterine, Cho Seong H, Chong-Neto Herberto Jose, Chu Derek K, Cingi Cemal, Compalati Enrico, Costa Raquel Albuquerque, Cvetkovski Biljana, Cardona Victoria, D'Amato Gennaro, Davies Janet M, Di Bona Danilo, Gonzalez Diaz Sandra N, Dimou Maria V, Doulaptsi Maria, Ferreira-da-Silva Renato, Gawlik Radoslaw, Calvo-Gil Mario, Gómez Maximiliano R, Gotua Maia, Grigoreas Christos, Guzman Maria Antonieta, House Rachel, Hyland Michael, Ierodiakonou Despo, Karavelia Aspasia, Keith Paul, Kisiel Marta, Kosak Tanja Soklic, Kosnik Mitja, Koyuncu Ilgim Vardaloglu, Kritikos Vicky, Litynska Justyna, Lombardi Carlo, Louis Gilles, Luo Xin, Martini Matteo, Meço Cem, Mesonjesi Eris, Mihaltan Florin, Moniuszko Marcin, Naclerio Robert N, Neisinger Sophia, Ollert Markus, Ordak Michal, Paoletti Giovanni, Parmelli Elena, Perdomo-Flores Edgar Arturo, Pereira Henrique, Pérez José Miguel Fuentes, Pham-Thi Nhan, Prokopakis Emmanuel, Ribeiro-Vaz Inês, Rolla Giovanni, Romantowski Jan, Rombaux Philippe, Rouadi Philip W, Ryan Dermot, Sadowska Ewelina, Sakurai Daiju, Salameh Laila, Serrano Elie, Da Silva Jane, Soyka Michael B, Specjalski Krzysztof, Tomic-Spiric Vesna, Stevanovic Katarina, Subramaniam Abirami, Thomander Tuuli, Tong Wu, Vachova Martina, van Hage Marianne, Wagenmann Martin, Ko Fanny Wai San, Werminghaus Pascal, Xepapadaki Paraskevi Vicky, Xiang Yi-Kui, Yang Qintai, Zhang He, Zuberbier Jaron, Fonseca João A
Аннотация
METHODS: The ARIA-EAACI 2024-2025 guideline panel issued recommendations following the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) evidence-to-decision framework. Several sources of evidence were used to inform panel judgements and recommendations, including systematic reviews, mHealth and pharmacovigilance data as well as a survey on costs.
RESULTS: Eight guideline questions concerning oral treatments for AR and three questions concerning ocular treatments were addressed. These questions led to the recommendations. Overall, these questions concern the choice between different classes of medication. They also discuss the role of oral antihistamines (OAH), leukotriene receptor antagonists (LTRA), ocular antihistamines (OcAH) and ocular mast cell stabilisers. Four questions had not been previously evaluated in ARIA guidelines, while, for the other four, there was a change in the strength or directionality of the recommendations. Overall, these guidelines recommend using intranasal corticosteroids over OAH and using OAH over LTRA. Moreover, they suggest using OAH over OcAH and suggest being against adding LTRA to OAH. Finally, considerations for choosing between different individual OAHs are presented.
CONCLUSION: This ARIA-EAACI 2024-2025 article supports patients, their caregivers and healthcare professionals in choosing oral and ocular treatments for AR. Decisions on treatment should consider the clinical variability of the disease, patients' values and the affordability of medications.