Progressive Immunotherapy-Related Mucocutaneous Eruption: A Mimicker of SJS-TEN.

Immune checkpoint inhibitors are an integral component of oncology treatment. Adverse systemic effects of this immune modulation are often manifested in the skin and, therefore, must be carefully described and characterized to inform clinical decision making in medically complex patients. Here we report 2 cases of progressive immunotherapy-related mucocutaneous eruption that resemble Stevens-Johnson Syndrome but is unique in its clinical and histopathologic presentation, supporting a distinction from classic medication-induced Stevens-Johnson syndrome and toxic epidermal necrolysis.