Case reports in oncology · 2024
JAK 2-Positive Diseases and Spontaneous Coronary Artery Dissection: Case Series.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Yasin Ahmed K A, Mohamed Shehab Fareed, Abdalla Elmustafa, Rao Girish, Alkhulaifi Abdulaziz M, Yassin Mohamed A, Mudawi Deena, Al-Mashdali Abdulrahman Fadhl, Kohla Samah, Ibrahim Feryal A, Soliman Dina, Carr Cornelia S
Аннотация
INTRODUCTION: Chronic myeloproliferative neoplasms (MPNs) such as polycythaemia vera (PV) and essential thrombocytosis are associated with atherosclerosis and cardiovascular events, especially if JAK2 mutation is there. In rare cases, also spontaneous coronary artery dissection (SCAD) can be seen.
CASE PRESENTATION: This case series describes two case reports of MPNs in which SCAD was found in both of them in addition to standard atherosclerosis. First one was about a 42-year-old man who was admitted for acute myocardial infarction (MI) and was later found to have PV and SCAD. The second one was about a 52-year-old man who was also admitted for acute MI and was later found to have SCAD and essential thrombocythemia. JAK2V617F missense mutation was found in both cases.
CONCLUSION: MPNs with JAK2 mutations are associated with SCAD in addition to usual atherosclerosis. This association needs further research.
CASE PRESENTATION: This case series describes two case reports of MPNs in which SCAD was found in both of them in addition to standard atherosclerosis. First one was about a 42-year-old man who was admitted for acute myocardial infarction (MI) and was later found to have PV and SCAD. The second one was about a 52-year-old man who was also admitted for acute MI and was later found to have SCAD and essential thrombocythemia. JAK2V617F missense mutation was found in both cases.
CONCLUSION: MPNs with JAK2 mutations are associated with SCAD in addition to usual atherosclerosis. This association needs further research.