Integrating Psychodermatology and Platelet-Rich Plasma Therapy in Various Dermatological Conditions: A Narrative Review.

Traditional dermatological care often prioritizes visible symptoms, while under-recognizing psychological distress and overlooking emerging regenerative therapies. This narrative review examines two adjunctive approaches: psychodermatology, which addresses the bidirectional relationship between psychological health and skin disease, and platelet-rich plasma (PRP), a minimally invasive regenerative treatment with demonstrated efficacy in acne scarring, alopecia, melasma, vitiligo, and wounds through growth factor-mediated repair. Psychodermatology, underpinned by the neuro-immuno-cutaneous system (NICS), highlights how psychological stress can exacerbate dermatological disease and impair quality of life (QoL). The mechanisms and clinical applications of both modalities are explored, alongside their potential to enhance patient-centered care in chronic skin conditions (CSCs). Integrating PRP and psychodermatology into practice may improve both clinical outcomes and QoL, highlighting the need for multidisciplinary, patient-centered care.