Oral diseases · 2026
Systematic Review and Meta-Analysis of the Management and Outcomes of Recurrent Ranulas.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Nguyen Kenny, Goodman Emily, Vibhute Mukta, Blake Lindsay, Richter Gresham T, Kompelli Anvesh
Аннотация
OBJECTIVE: To systematically review and compare recurrence rates associated with different management strategies for simple and plunging ranulas.
METHODS: A PRISMA-guided search of PubMed, Embase, Web of Science, Scopus, and CINAHL was performed. Studies reporting post-treatment outcomes of ranulas with clearly defined initial management strategies were included. Two reviewers independently screened studies and extracted data on ranula subtype, treatment details, duration of follow-up, and recurrence. Risk of bias was assessed using study design-appropriate tools. Given the predominance of retrospective case series with heterogenous designs and incomplete outcome reporting, quantitative pooling was not feasible; results were synthesized descriptively.
RESULTS: Seventy-one studies comprising 809 patients (563 simple, 246 plunging) met inclusion criteria. Excision with ipsilateral sublingual gland removal (30%) was associated with recurrence rates below 10%. Excision without gland removal and marsupialization demonstrated higher and more variable recurrence rates, ranging from 15%-30% across cohorts. Sclerotherapy outcomes varied by agent, with recurrence rates of 3%-10% for bleomycin and over 50% for OK-432, particularly in plunging ranulas. Most recurrences occurred within 3-6 months.
CONCLUSION: Sublingual gland excision was consistently associated with the lowest recurrence rates, while outcomes following marsupialization and sclerotherapy varied by technique and agent.
METHODS: A PRISMA-guided search of PubMed, Embase, Web of Science, Scopus, and CINAHL was performed. Studies reporting post-treatment outcomes of ranulas with clearly defined initial management strategies were included. Two reviewers independently screened studies and extracted data on ranula subtype, treatment details, duration of follow-up, and recurrence. Risk of bias was assessed using study design-appropriate tools. Given the predominance of retrospective case series with heterogenous designs and incomplete outcome reporting, quantitative pooling was not feasible; results were synthesized descriptively.
RESULTS: Seventy-one studies comprising 809 patients (563 simple, 246 plunging) met inclusion criteria. Excision with ipsilateral sublingual gland removal (30%) was associated with recurrence rates below 10%. Excision without gland removal and marsupialization demonstrated higher and more variable recurrence rates, ranging from 15%-30% across cohorts. Sclerotherapy outcomes varied by agent, with recurrence rates of 3%-10% for bleomycin and over 50% for OK-432, particularly in plunging ranulas. Most recurrences occurred within 3-6 months.
CONCLUSION: Sublingual gland excision was consistently associated with the lowest recurrence rates, while outcomes following marsupialization and sclerotherapy varied by technique and agent.