Auto Immune Glial Fibrillary Acidic Protein Astrocytopathy Coexistent with Positivity for Anti-NH2-terminal of α-enolase Antibodies.

A 46-year-old woman presented with acute disturbance of consciousness, ataxia, and urinary retention. Although Hashimoto's encephalopathy was initially suspected due to the detection of serum anti-NH2-terminal α-enolase (NAE) antibodies, glial fibrillary acidic protein (GFAP)-astrocytopathy was also considered probable due to urinary retention. An additional examination revealed positive results for both anti-GFAP and anti-NAE antibodies. This case highlights the importance of considering antibodies to be examined based on clinical features, even in the presence of antibodies.