Ocular immunology and inflammation · 2026
The Association Between IgA Nephropathy and Uveitis Using Clinical Setting Data.
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Lishinsky-Fischer Natan, Gork Ittamar, Jacobs Aviya R, Corcos Yaacov, Levy Jaime
Аннотация
PURPOSE: To evaluate the association between IgA nephropathy (IgAN) and the incidence of uveitis.
METHODS: Using a multicenter global research network, adult patients with IgA nephropathy (IgAN) were compared to a control cohort of patients diagnosed with nephrosclerosis following a renal biopsy. Propensity score matching (PSM) was performed to balance baseline characteristics between the IgAN and control cohort.
RESULTS: 4,431 and 8,307 patients were identified for the IgAN and control groups, respectively. After PSM, 3,835 patients were included in both groups. A total of 18 patients (0.474%) in the IgAN group developed uveitis, compared with ≤10 patients (0.263%) in the control group. This result corresponds to a HR of 2.21 (95% CI [1.02, 4.80]; p = 0.0394).
CONCLUSIONS: Patients with IgAN had a higher risk of developing uveitis compared with matched controls with nephrosclerosis. These findings suggest a potential association between IgAN and ocular inflammatory disease. Further research is needed in order to assess this potential association.
METHODS: Using a multicenter global research network, adult patients with IgA nephropathy (IgAN) were compared to a control cohort of patients diagnosed with nephrosclerosis following a renal biopsy. Propensity score matching (PSM) was performed to balance baseline characteristics between the IgAN and control cohort.
RESULTS: 4,431 and 8,307 patients were identified for the IgAN and control groups, respectively. After PSM, 3,835 patients were included in both groups. A total of 18 patients (0.474%) in the IgAN group developed uveitis, compared with ≤10 patients (0.263%) in the control group. This result corresponds to a HR of 2.21 (95% CI [1.02, 4.80]; p = 0.0394).
CONCLUSIONS: Patients with IgAN had a higher risk of developing uveitis compared with matched controls with nephrosclerosis. These findings suggest a potential association between IgAN and ocular inflammatory disease. Further research is needed in order to assess this potential association.