Ophthalmology science · 2026
Consensus Guidance for Screening, Classification, and Treatment of Retinopathy Associated with Incontinentia Pigmenti.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Moon Jade Y, Abbott Becky, Berrocal Audina, Chen Connie, Chen Xi, Ferrone Philip, Fete Mary, Goldberg Morton F, Grange Dorothy K, Han Ian, Hartnett M Elizabeth, Henderson Robert H, Nudleman Eric, Ozdek Sengul, Sather Richard N, Somani Nicole, Wilson Reid, Montezuma Sandra R, Campbell J Peter
Аннотация
OBJECTIVE: Incontinentia pigmenti (IP) is a rare genetic condition that can lead to blindness. Clinical practice for screening for the ocular complications of IP is variable. Current literature lacks consensus for the screening, classification, and treatment of IP-related eye disease despite substantial risk of retinal detachment (RD) and blindness. This report summarizes the state of knowledge and establishes expert guidance for screening, classification, and treatment of IP-related eye disease from the International Conference on Incontinentia Pigmenti (ICIP) sponsored by the National Foundation for Ectodermal Dysplasias in February 2025.
DESIGN: Literature review.
SUBJECTS: Images from authors' patients with a diagnosis of IP were included in this study.
METHODS: We review the current literature on screening and treatment of retinal complications of IP and provide guidance on disease screening, classification, and management from the ICIP in 2025.
MAIN OUTCOME MEASURES: Screening, treatment, and surveillance options were reviewed.
RESULTS: The ICIP established guidance to support parents and ophthalmologists in appropriate screening and treatment of infants diagnosed with IP. Due to the high prevalence of retinal involvement in IP, infants diagnosed with IP should receive an early, comprehensive retinal examination, ideally with widefield fluorescein angiography. Like treatment considerations for other pediatric diseases with retinal ischemia, treatment concentrates acutely on regression of neovascularization and strategies to reduce incidence of RDs later in life.
CONCLUSIONS: Incontinentia pigmenti is a rare but complex multisystem disorder with the potential for serious retinal complications. Careful ophthalmic screening and surveillance are crucial to optimize patients' visual outcomes.
FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
DESIGN: Literature review.
SUBJECTS: Images from authors' patients with a diagnosis of IP were included in this study.
METHODS: We review the current literature on screening and treatment of retinal complications of IP and provide guidance on disease screening, classification, and management from the ICIP in 2025.
MAIN OUTCOME MEASURES: Screening, treatment, and surveillance options were reviewed.
RESULTS: The ICIP established guidance to support parents and ophthalmologists in appropriate screening and treatment of infants diagnosed with IP. Due to the high prevalence of retinal involvement in IP, infants diagnosed with IP should receive an early, comprehensive retinal examination, ideally with widefield fluorescein angiography. Like treatment considerations for other pediatric diseases with retinal ischemia, treatment concentrates acutely on regression of neovascularization and strategies to reduce incidence of RDs later in life.
CONCLUSIONS: Incontinentia pigmenti is a rare but complex multisystem disorder with the potential for serious retinal complications. Careful ophthalmic screening and surveillance are crucial to optimize patients' visual outcomes.
FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.