International ophthalmology · 2026
Conjunctival biopsy findings associated with fibrosis and sequelae in ocular Mucous membrane pemphigoid.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Ringer Ariana, Smichowski Andrea, Siegrist Carlos Nuncio, Grossi German Daniel, Gómez Ramiro Adrian, Zarate Jorge Oscar, Rosa Javier Eduardo, Brance Maria Lorena, Pérez Ana Rosa, Gandino Ignacio Javier
Аннотация
PURPOSE: Ocular mucous membrane pemphigoid (OcMMP) leads to fibrosis of the conjunctiva with potential sequelae. Our objective was to describe biopsies from patients with OcMMP and identify biopsy characteristics associated with fibrosis and sequelae.
METHODS: Patients with histologically confirmed OcMMP were selected. Fibrosis grades were defined according to Foster's stages. The subjects were divided into two groups: early stages (0 and 1) versus later stages (2, 3, and 4). A Cox multivariate analysis was performed to determine whether immunofluorescence deposits were associated with sequelae.
RESULTS: Fifty-seven patients were included. The mean age at diagnosis was 62.7 (SD 13.2) years, and 41 (71.9%) were women. The follow-up time was 1.5 years (IQR 0.3-3). Patients with early Foster were 50.9%. The presence of mast cells was associated with early stages, whereas eosinophils were associated with later stages at the time of diagnosis. In the multivariate Cox regression analysis, the presence of IgA deposits was associated with developing sequelae (HR 10.8; IC 95% 1.3-92.9; p 0.03).
CONCLUSION: Eosinophils were more frequently observed in patients with advanced Foster stages, and IgA was associated with the sequelae.
METHODS: Patients with histologically confirmed OcMMP were selected. Fibrosis grades were defined according to Foster's stages. The subjects were divided into two groups: early stages (0 and 1) versus later stages (2, 3, and 4). A Cox multivariate analysis was performed to determine whether immunofluorescence deposits were associated with sequelae.
RESULTS: Fifty-seven patients were included. The mean age at diagnosis was 62.7 (SD 13.2) years, and 41 (71.9%) were women. The follow-up time was 1.5 years (IQR 0.3-3). Patients with early Foster were 50.9%. The presence of mast cells was associated with early stages, whereas eosinophils were associated with later stages at the time of diagnosis. In the multivariate Cox regression analysis, the presence of IgA deposits was associated with developing sequelae (HR 10.8; IC 95% 1.3-92.9; p 0.03).
CONCLUSION: Eosinophils were more frequently observed in patients with advanced Foster stages, and IgA was associated with the sequelae.