Acta oto-laryngologica. Supplementum · 2010
Inner ear drug delivery system from the clinical point of view.
Клиническое исследование I фазыКлиническое исследование II фазыСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Sakamoto Tatsunori, Nakagawa Takayuki, Horie Rie T, Hiraumi Harukazu, Yamamoto Norio, Kikkawa Yayoi S, Ito Juichi
Аннотация
CONCLUSION: Three types of inner ear drug delivery systems (DDS) that were ready to be applied in clinics were developed.
OBJECTIVES: To develop clinically applicable inner ear DDS for the treatment of inner ear disorders.
METHODS: Inner ear DDS using clinically applicable materials were developed and evaluated.
RESULTS: The systemic application of stealth-type nanoparticles encapsulating betamethasone provided superior therapeutic results for the treatment of noise-induced hearing loss compared with the systemic application of betamethasone in mice. Microparticles made of biodegradable polymer (poly (lactic/glycolic) acid, PLGA) encapsulating lidocaine were placed on the round window membrane of guinea pigs, and resulted in reasonable concentrations of lidocaine in the cochlea without serious adverse effects. The phase I/IIa clinical trial of the application of insulin-like growth factor-1 (IGF-1) in combination with gelatin hydrogel on the round window membrane was conducted, recruiting patients with acute sensorineural hearing loss after the failure of systemic application of steroids.
OBJECTIVES: To develop clinically applicable inner ear DDS for the treatment of inner ear disorders.
METHODS: Inner ear DDS using clinically applicable materials were developed and evaluated.
RESULTS: The systemic application of stealth-type nanoparticles encapsulating betamethasone provided superior therapeutic results for the treatment of noise-induced hearing loss compared with the systemic application of betamethasone in mice. Microparticles made of biodegradable polymer (poly (lactic/glycolic) acid, PLGA) encapsulating lidocaine were placed on the round window membrane of guinea pigs, and resulted in reasonable concentrations of lidocaine in the cochlea without serious adverse effects. The phase I/IIa clinical trial of the application of insulin-like growth factor-1 (IGF-1) in combination with gelatin hydrogel on the round window membrane was conducted, recruiting patients with acute sensorineural hearing loss after the failure of systemic application of steroids.