MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1016/j.neurobiolaging.2024.05.015

Медицинская библиотека · Neurobiology of aging · 2024

Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease.

Rodríguez-Fernández Blanca, Sánchez-Benavides Gonzalo, Genius Patricia, Minguillon Carolina, Fauria Karine, De Vivo Immaculata, Navarro Arcadi, Molinuevo Jose Luis, Gispert Juan Domingo, Sala-Vila Aleix, Vilor-Tejedor Natalia, Crous-Bou Marta, ALFA study

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

INTRODUCTION

Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD.

METHODS

A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested.

RESULTS

Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group.

DISCUSSION: Results suggest a potential role of telomeres in the cognitive aging process with sex-specific patterns.

Для цитирования: Rodríguez-Fernández Blanca, Sánchez-Benavides Gonzalo, Genius Patricia, Minguillon Carolina, Fauria Karine, De Vivo Immaculata, Navarro Arcadi, Molinuevo Jose Luis, Gispert Juan Domingo, Sala-Vila Aleix, Vilor-Tejedor Natalia, Crous-Bou Marta, ALFA study. Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease.. Neurobiology of aging. 2024. DOI: 10.1016/j.neurobiolaging.2024.05.015.

Предметные рубрики MeSH

HumansAlzheimer DiseaseFemaleMaleTelomereCognitionMiddle AgedLeukocytesMemory, EpisodicCross-Sectional StudiesRiskAgedCohort StudiesAgingCognitive AgingBiomarkers
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.