Retina (Philadelphia, Pa.) · 2026
Clinical and microbiological characteristics of multidrug-resistant acute bacterial endophthalmitis after cataract surgery. Endophthalmitis Management Study Report # 8.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Das Taraprasad, Belenje Akash, Joseph Joveeta, Pandey Suchita, Pandya Dhanush, Behera Umesh C, Dave Vivek Pravin
Аннотация
PURPOSE: Report the clinico-microbiological characteristics of multidrug-resistant acute postcataract bacterial endophthalmitis.
METHODS: Consecutive 32 cases from a prospective multicenter study in India were analyzed for the clinical features, presenting visual acuity, and inflammation score before and 3 months after treatment. Absolute risk reduction and number needed to treat to avoid globe loss were calculated.
RESULTS: The multidrug-resistant incidence was 7.8% (32/410). It included 28 gram-negative bacilli (GNB, 87.5%) and 4 gram-positive cocci (GPC, 12.5%). The presenting visual acuity was light perception to hand motions in 93.9% (30/32) of patients. The mean inflammation score was 17.34 ± 3.96. The primary treatment was vitrectomy and intravitreal antibiotics; all patients required a second intervention-vitreous lavage and intravitreal antibiotics (mean 2.43). GNBs were resistant to fluoroquinolones, aminoglycosides, and cephalosporins (39.3% each) and polymyxins (17.6%). Most amikacin- and ceftazidime-resistant (81.8%) GNBs were susceptible to colistin. After treatment, 9.4% of eyes developed phthisis, 46.9% did not improve vision, and 9.4% of eyes had ≥20/40. The absolute risk reduction was higher and the number needed to treat was lower to avoid one globe loss with colistin than with other antibiotics.
CONCLUSION: Colistin could be an alternative to treating multidrug-resistant postcataract endophthalmitis caused by gram-negative bacilli in India.
METHODS: Consecutive 32 cases from a prospective multicenter study in India were analyzed for the clinical features, presenting visual acuity, and inflammation score before and 3 months after treatment. Absolute risk reduction and number needed to treat to avoid globe loss were calculated.
RESULTS: The multidrug-resistant incidence was 7.8% (32/410). It included 28 gram-negative bacilli (GNB, 87.5%) and 4 gram-positive cocci (GPC, 12.5%). The presenting visual acuity was light perception to hand motions in 93.9% (30/32) of patients. The mean inflammation score was 17.34 ± 3.96. The primary treatment was vitrectomy and intravitreal antibiotics; all patients required a second intervention-vitreous lavage and intravitreal antibiotics (mean 2.43). GNBs were resistant to fluoroquinolones, aminoglycosides, and cephalosporins (39.3% each) and polymyxins (17.6%). Most amikacin- and ceftazidime-resistant (81.8%) GNBs were susceptible to colistin. After treatment, 9.4% of eyes developed phthisis, 46.9% did not improve vision, and 9.4% of eyes had ≥20/40. The absolute risk reduction was higher and the number needed to treat was lower to avoid one globe loss with colistin than with other antibiotics.
CONCLUSION: Colistin could be an alternative to treating multidrug-resistant postcataract endophthalmitis caused by gram-negative bacilli in India.