Expression of YME1 Like 1 ATPase Increases With the Stage of Adrenocortical Carcinoma Tissue and Is Associated With Poor Patient Prognosis.

BACKGROUND/AIM: Adrenocortical carcinoma (ACC) is an endocrine tumor arising in the adrenal cortex. Although its incidence is extremely low, it is highly malignant, rapidly proliferating, and infiltrating surrounding organs, resulting in a poor prognosis. YME1 Like 1 ATPase (YME1L1) is an ATP-dependent metalloprotease that regulates mitochondrial proteostasis. Recently, a correlation between YME1L1 expression and the prognosis of several cancers has been reported. However, no studies have examined the expression level of YME1L1 mRNA in ACC tissues or the relationship between YME1L1 expression and the prognosis of ACC patients. Therefore, there is a need to investigate the relationship between YME1L1 expression and the prognosis of ACC patients.

MATERIALS AND

METHODS

YME1L1 mRNA expression and survival in ACC patients were analyzed using the TCGA database with the UALCAN and GEPIA platforms.

RESULTS

YME1L1 mRNA expression was significantly increased in ACC tissues from stage IV patients compared with stage I, II, and III patients (p<0.0005, p<0.05, and p<0.05, respectively). Furthermore, increased YME1L1 mRNA expression was inversely correlated with survival and disease-free interval in ACC patients (p<0.01).

CONCLUSION

YME1L1 is highly expressed in ACC tissues and inversely correlated with patient prognosis, suggesting its potential as a prognostic biomarker for ACC patients and providing new insights into its role in tumor biology. Further studies are needed to elucidate its therapeutic significance and mechanistic contribution to the malignant progression of ACC.