Solitary Fibrous Tumors of the Submandibular Gland: A Case Report.

Solitary fibrous tumors (SFTs) are uncommon neoplasms that arise from the pleura. Although they can appear in various extrathoracic areas, they are uncommon in the submandibular gland. This paper reports a 37-year-old woman with a spherical, hypoechogenic mass measuring 13 × 37 mm and having a regular boundary on the left side of the submandibular gland. The lesion was surgically excised with a less than 1 mm margin. Following histopathological and immunohistochemical examination, the diagnosis of SFT was confirmed. Staining showed that the lesion was negative for vimentin, AE3/CKAE1, calponin, SOX10, desmin, and S-100 and diffusely positive for CD34, CD99 (MIC-2), SMA, BCL2, and STAT-6. Patient underwent postoperative radiation and was observed for one year without showing any symptoms of metastases or recurrence. The study indicates that SFTs of the submandibular gland should be considered in the differential diagnosis of submandibular soft-tissue tumors, despite their rarity.