Медицинская библиотека · bioRxiv : the preprint server for biology · 2026
The Vertebrate Genomes Project Phase I: A global reference genome resource.
Formenti Giulio, Absolon Dominic E, Abueg Linelle Ann L, Ackerman Francine, Al-Ajli Farooq O, Aleixo Alexandre, Antunes Agostinho, Arcila Dahiana, Audet Jean-Nicolas, Balacco Jennifer R, Beavan Alan J S, Belov Katherine, Betancur-R Ricardo, Bidwell Shelby L, Biegler Matthew T, Bista Iliana, Blaxter Mark, Boyer Kevin, Braasch Ingo, Bradbury Ian R, Brajuka Nadolina, Bronikowski Anne M, Brown Tom, Butler George, Cao Shuo, Charvel Eduardo, Chen Ying, Ciofi Claudio, Clawson Hiram M, Collins Joanna C, Correard Solenne, Corrigan Shannon, Couture Mélanie, Crawford Andrew J, D'Alessandre Nathália D, da Conceicao Helena B, da Fonseca Rute R, Daigavane Minoli, Dalapicolla Jeronymo, de Bruyn Mark, de Jong Emma, De Panis Diego N, Detrich H William, Scott Carol DeWeese, Diekhans Mark, Duarte Erick, Durbin Richard, Escalona Merly, Eschenbrenner Michel, Fedrigo Olivier, Fenn Jonathan, Flannery Patrick, Forde Niamh, Gable Simone M, Galante Pedro A, Ganesan Rajee, Gardiner Amanda, Garrison Erik, Gemmell Neil J, Gilbert M Thomas P, Giudicelli François, Gonçalves Tássia M, Guardia Gabriela D A, Guarracino Andrea, Gupta Anshu, Haase Bettina, Hays Delson, Hickey Glenn, Hiller Michael, Hime Paul M, Hogg Carolyn J, Horan Kathleen M, Howe Kerstin, Jackson Danny, Jain Nivesh, Kang Lin, Kliver Sergei, Ko Byung June, Koepfli Klaus-Peter, Komissarov Aleksey, Komoroske Lisa M, Koo Bonhwang, Koren Sergey, Korlach Jonas, Kovacic Iva, Krasheninnikova Ksenia, Kuderna Lukas F, Langlois Ryan A, Lariviere Delphine, Larkin Denis M, Lee Chul, Lee Young Ho, Lewin Harris A, Lim Daven, Lou Runyang Nicolas, Mak Sarah S, Makova Kateryna D, Marín-Gual Laia, Marques-Bonet Tomas, Martin Fergal J, Mathers Thomas C, Mazzoni Camila J, McCaffrey Kirsty, McCarthy Shane A, Medico Jack A, Mercuri Rafael L V, Meyer Axel, Michalak Pawel, Mirarab Siavash, Morin Phillip A, Mountcastle Jacquelyn, Murphy Robert W, Murphy Terence D, Myers Eugene W, Naylor Gavin J, Near Thomas, Nekrutenko Anton, Ning Zemin, Novak Ben J, O'Brien Michelle F, O'Connell Mary J, O'Toole Brian P, Paez Sadye, Paten Benedict, Paulini Michael, Pelan Sarah E, Pennell Matt, Pfenning Andreas R, Phillippy Adam M, Pinto Brendan, Pippel Martin, Popova Marina, Prylutskyi Maksym, Rhie Arang, Crollius Hugues Roest, Ruiz-Herrera Aurora, Ryder Oliver, Safonova Yana, Santos Camilla A, Schatz Michael C, Secomandi Simona, Shaffer H B, Shalmiyev Lauren, Shapiro Beth, Smith Jeramiah J, Sollitto Marco, Sotero-Caio Cibele G, Steiner Cynthia C, Sudmant Peter H, Sweeney Deacon J, Talbot Samuel C, Taylor Christopher H, Teeling Emma C, Thibaud-Nissen Françoise, Tilley Tatiana, Timoshevskaya Nataliya, Traore Patrick, Turakhia Yatish, Uliano-Silva Marcela, Venditti Chris, Venkatesh Byrappa, Vernes Sonja C, Warren Wesley C, Whelan Conor V, Wilson Melissa A, Winkler Sylke, Wood Jonathan M, Zhang Guojie, Zhao Guoyan, Jarvis Erich D, Vertebrate Genomes Project Consortium Phase I
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Аннотация
The Vertebrate Genomes Project (VGP) aims to produce complete and near-error-free reference genomes for all ~70,000 extant vertebrate species1. Organized in four phases, it progressively targets all vertebrate orders, families, genera, and eventually all species. Here we present the completion of VGP Phase I, delivering reference genomes for ~95% of vertebrate orders, along with additional lineages within those orders, totaling 816 species and 1.6 trillion base pairs of main haplotype sequence. These genomes were assembled and annotated over an 8-year period (2018-2026) of rapid advances in genome sequencing, assembly, and annotation methods2-4, alongside the growth of associated consortium initiatives and international collaborations5-9. They represent some of the highest-quality vertebrate genomes currently available, and most have become the primary reference for their respective species in public databases. Comparative analyses across a subset of 579 species when we reached a threshold of 85% of orders allowed us to reconstruct the genome of the last common ancestor of all vertebrates 500 million years ago, identify diverse modes of sex chromosome evolution, reveal clade-specific three-dimensional genome architecture, discover methylated epigenetic landscapes across vertebrates, and provide a framework for studying gene and pseudogene evolution, immune loci, cancer-associated genes, and other trait-associated loci. Approximately a quarter of this subset are listed as Vulnerable to Critically Endangered by the IUCN Red List of Threatened Species, and have enabled more advanced genomic investigations of extinction risk. VGP Phase I delivers a reference backbone for vertebrate genomics, enabling discoveries that would otherwise remain out of reach across evolution, conservation, and medicine.
Для цитирования: Formenti Giulio, Absolon Dominic E, Abueg Linelle Ann L, Ackerman Francine, Al-Ajli Farooq O, Aleixo Alexandre, Antunes Agostinho, Arcila Dahiana, Audet Jean-Nicolas, Balacco Jennifer R, Beavan Alan J S, Belov Katherine, Betancur-R Ricardo, Bidwell Shelby L, Biegler Matthew T, Bista Iliana, Blaxter Mark, Boyer Kevin, Braasch Ingo, Bradbury Ian R, Brajuka Nadolina, Bronikowski Anne M, Brown Tom, Butler George, Cao Shuo, Charvel Eduardo, Chen Ying, Ciofi Claudio, Clawson Hiram M, Collins Joanna C, Correard Solenne, Corrigan Shannon, Couture Mélanie, Crawford Andrew J, D'Alessandre Nathália D, da Conceicao Helena B, da Fonseca Rute R, Daigavane Minoli, Dalapicolla Jeronymo, de Bruyn Mark, de Jong Emma, De Panis Diego N, Detrich H William, Scott Carol DeWeese, Diekhans Mark, Duarte Erick, Durbin Richard, Escalona Merly, Eschenbrenner Michel, Fedrigo Olivier, Fenn Jonathan, Flannery Patrick, Forde Niamh, Gable Simone M, Galante Pedro A, Ganesan Rajee, Gardiner Amanda, Garrison Erik, Gemmell Neil J, Gilbert M Thomas P, Giudicelli François, Gonçalves Tássia M, Guardia Gabriela D A, Guarracino Andrea, Gupta Anshu, Haase Bettina, Hays Delson, Hickey Glenn, Hiller Michael, Hime Paul M, Hogg Carolyn J, Horan Kathleen M, Howe Kerstin, Jackson Danny, Jain Nivesh, Kang Lin, Kliver Sergei, Ko Byung June, Koepfli Klaus-Peter, Komissarov Aleksey, Komoroske Lisa M, Koo Bonhwang, Koren Sergey, Korlach Jonas, Kovacic Iva, Krasheninnikova Ksenia, Kuderna Lukas F, Langlois Ryan A, Lariviere Delphine, Larkin Denis M, Lee Chul, Lee Young Ho, Lewin Harris A, Lim Daven, Lou Runyang Nicolas, Mak Sarah S, Makova Kateryna D, Marín-Gual Laia, Marques-Bonet Tomas, Martin Fergal J, Mathers Thomas C, Mazzoni Camila J, McCaffrey Kirsty, McCarthy Shane A, Medico Jack A, Mercuri Rafael L V, Meyer Axel, Michalak Pawel, Mirarab Siavash, Morin Phillip A, Mountcastle Jacquelyn, Murphy Robert W, Murphy Terence D, Myers Eugene W, Naylor Gavin J, Near Thomas, Nekrutenko Anton, Ning Zemin, Novak Ben J, O'Brien Michelle F, O'Connell Mary J, O'Toole Brian P, Paez Sadye, Paten Benedict, Paulini Michael, Pelan Sarah E, Pennell Matt, Pfenning Andreas R, Phillippy Adam M, Pinto Brendan, Pippel Martin, Popova Marina, Prylutskyi Maksym, Rhie Arang, Crollius Hugues Roest, Ruiz-Herrera Aurora, Ryder Oliver, Safonova Yana, Santos Camilla A, Schatz Michael C, Secomandi Simona, Shaffer H B, Shalmiyev Lauren, Shapiro Beth, Smith Jeramiah J, Sollitto Marco, Sotero-Caio Cibele G, Steiner Cynthia C, Sudmant Peter H, Sweeney Deacon J, Talbot Samuel C, Taylor Christopher H, Teeling Emma C, Thibaud-Nissen Françoise, Tilley Tatiana, Timoshevskaya Nataliya, Traore Patrick, Turakhia Yatish, Uliano-Silva Marcela, Venditti Chris, Venkatesh Byrappa, Vernes Sonja C, Warren Wesley C, Whelan Conor V, Wilson Melissa A, Winkler Sylke, Wood Jonathan M, Zhang Guojie, Zhao Guoyan, Jarvis Erich D, Vertebrate Genomes Project Consortium Phase I. The Vertebrate Genomes Project Phase I: A global reference genome resource.. bioRxiv : the preprint server for biology. 2026. DOI: 10.64898/2026.06.24.732306.
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