Successful Management of Pyoderma Gangrenosum in a Patient With Concurrent Behçet's Disease and Familial Mediterranean Fever: A Case Report.

Pyoderma gangrenosum (PG) is a rare ulcerative skin condition. Familial Mediterranean fever (FMF) and Behçet's disease (BD) are autoinflammatory disorders common in Mediterranean populations. The coexistence of FMF and BD is unusual, and the presence of PG alongside both is even rarer. We present a case of a 51-year-old male diagnosed with both BD and FMF who developed PG during treatment. His PG lesion was managed with a tailored regimen that included topical hydrocortisone acetate with fusidic acid, colchicine, topical tacrolimus, oral prednisone, and intravenous infliximab, which led to the successful healing of the PG lesion. This case underscores the need for specialized approaches to manage overlapping autoinflammatory conditions.