[Autonomic Dysfunction in ATTR Amyloidosis].

In addition to polyneuropathy, patients with hereditary transthyretin amyloidosis (ATTRv) often experience autonomic dysfunction, which reduces quality of life. Compared with patients with ATTRv from endemic areas, those from non-endemic areas rarely develop autonomic dysfunction as an initial symptom. Conversely, autonomic dysfunction can be a diagnostic red flag in patients from non-endemic areas without a family history. Autonomic dysfunction in patients with wild-type transthyretin amyloidosis (ATTRwt) has only recently been reported. However, further knowledge is needed to clarify its pathophysiology.