Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026
Heterogeneity of miRNAs in Salivary Gland Neoplasms: An Exploratory Pilot Study.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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de Santana Dandara Andrade, Braga Poliana Ramos, Ribeiro Daniel Araki, Cury Patricia Ramos, de Sena Ana Carolina Velasco Pondé, de Aquino Xavier Flávia Caló, Soares Fernando Augusto, de Araújo Iguaracyra Barreto, Marchi Fabio Albuquerque, Freitas Valéria Souza, Coutinho-Camillo Cláudia Malheiros, Dos Santos Jean Nunes
Аннотация
INTRODUCTION: MicroRNAs (miRNAs) are small RNAs that have been associated with tumourigenesis and tumour progression and that play an important role in the pathogenesis of salivary gland neoplasms. The aim of this study was to evaluate the global miRNA expression profile in a sample of salivary gland neoplasms.
METHODS: Cases of pleomorphic adenoma (n = 4), adenoid cystic carcinoma (n = 4) and mucoepidermoid carcinoma (n = 4) were studied by real-time RT-PCR.
RESULTS: The main up-regulated miRNAs were hsa-miR-373, hsa-miR-675, hsa-miR-508, hsa-miR-1290 and hsa-miR-483-3p, while hsa-miR-105 and hsa-let-7f-1 were among the most down-regulated miRNAs compared to the normal salivary gland. Hsa-miR-106b, hsa-miR-142-5p, hsa-miR-622, hsa-miR-642, hsa-miR-574-3p and hsa-miR-486 were significantly differentially expressed (p < 0.05) when each neoplasm and normal glandular tissue were compared.
CONCLUSION: This study described the global molecular signature of miRNAs in benign and malignant salivary gland neoplasms and provided preliminary evidence of miRNA dysregulation, suggesting a potential association between specific miRNA signatures and molecular pathways implicated in tumour progression.
METHODS: Cases of pleomorphic adenoma (n = 4), adenoid cystic carcinoma (n = 4) and mucoepidermoid carcinoma (n = 4) were studied by real-time RT-PCR.
RESULTS: The main up-regulated miRNAs were hsa-miR-373, hsa-miR-675, hsa-miR-508, hsa-miR-1290 and hsa-miR-483-3p, while hsa-miR-105 and hsa-let-7f-1 were among the most down-regulated miRNAs compared to the normal salivary gland. Hsa-miR-106b, hsa-miR-142-5p, hsa-miR-622, hsa-miR-642, hsa-miR-574-3p and hsa-miR-486 were significantly differentially expressed (p < 0.05) when each neoplasm and normal glandular tissue were compared.
CONCLUSION: This study described the global molecular signature of miRNAs in benign and malignant salivary gland neoplasms and provided preliminary evidence of miRNA dysregulation, suggesting a potential association between specific miRNA signatures and molecular pathways implicated in tumour progression.