Sulfasalazine-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome in a Patient With Rheumatoid Arthritis.

Because of its non-specific presentation and slow start, drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe and frequently underdiagnosed hypersensitivity reaction. In this case study, we discuss a 62-year-old lady who had been using sulfasalazine treatment for rheumatoid arthritis and presented to the emergency room with an extensive erythematous rash that was particularly noticeable on her lower limbs. She was found to have eyelid puffiness, nausea, and chills as well. Based on established diagnostic criteria, imaging scans, laboratory data, and clinical indicators, DRESS syndrome was diagnosed. This case emphasizes how important it is to identify DRESS syndrome early and be more clinically vigilant by adapting a timely multidisciplinary strategy to manage it successfully and avoid major systemic consequences.