[Late endogenous psychoses in light of clinico-genealogic research].

The families of 170 probands with late manifest endogenic psychoses (schizophrenia and manic-depressive psychoses) were studied. Late schizophrenia was found to be genetically related to schizophrenia on the whole. The families of patients with late schizophrenia were characterized by accumulation of typical schizophrenic psychoses and schizoid anomalies of the character. In the parents and siblings of such patients the rate of schizophrenia was significantly lower than in the families of patients with early manifestations. In the children of probands the risk of schizophrenia development was approximately identical in both late and early manifestations. The families of patients with late manic-depressive psychosis presented the accumulation of both affective and schizophrenic psychoses. The frequency of the latter grew from generation to generation.