Techniques for the assessment of volume status in patients with end stage renal disease.

While advances in assessing extracellular volume status have occurred, no methodology is sufficiently robust and accurate in all patients to recommend routine use in clinical practice. All of the methods described also perform best when measured serially in patients and when correlated with other ancillary methods of volume assessment such as body weight, physical examination and determination of vital signs and symptomatology. Perhaps, the best method for assessing and modifying dry weight is to utilize multiple complementary methods such as advocated by Ronco et in the “5B” approach (39). In this approach, the clinician utilizes data from: fluid balance (body weight changes), blood pressure, biomarkers (such as the natriuretic peptides), bioimpedance, and blood volume changes. Body (thoracic and IVC) ultrasound can also be included (Fig. 1). These combined data sources will likely lead to greater detection of subtle volume overload, a finding likely to contribute to excess mortality and morbidity. Clinical trials of such strategies are needed to better inform clinicians.