Left Ventricular Hemodynamics: Pre versus Post Mitral Valve Prolapse Repair.

Mitral valve prolapse (MVP), affecting around 2-3 percent of the adult population in the United States, is a common valvular heart disease marked by the impaired closure of mitral valve leaflets, resulting in regurgitation when the left ventricle (LV) contracts. While surgical treatment, including mitral valve repair (MVRe) or mitral valve replacement (MVRp), is the only definitive intervention, understanding the impact of these procedures on LV hemodynamics, especially regarding diastolic filling vortices and LV pumping efficiency, is crucial for evaluating post-surgery cardiac remodeling. In this study, we utilized a recently developed pipeline that combines standard cine cardiac magnetic resonance imaging (CMR) with phase-contrast magnetic resonance imaging (PC-MRI) data to model patientspecific fluid-structure interaction (FSI) in the LV. We used this pipeline to examine alterations in LV flow patterns in one MVP patient before and after MVRe. Findings indicate a reduction in the number of vortices and the LV volumetric kinetic energy changes post-MVRe. Studying LV hemodynamic characteristics pre- and post-MVRe, obtained from FSI modeling, and their relationship to LV diastolic and systolic functional indices holds promise for improved design of MV surgery in MVP.