[Effect of immunotherapy on the level of immunoglobulin in serum of women with pruritus of the vulva].

This study was performed in 52 women in their early postmenopausal period, divided into two equal groups. The control group included women with menopausal symptoms only, women in the study group demonstrated also pruritus. All women were on estrogen replacement therapy, additionally a bacterial auto-vaccine was administered in the study group. The level of IgG, IgA, IgM was determined by radioimmunodiffusion, IgE with an immunoenzymatic method. It was found that women with pruritus of the vulva had lower levels of IgG and IgM and higher levels of IgA and IgE, as compared with the control group. The auto-vaccine caused a significant (p < 0.05) increase of IgG and IgM and significant (p < 0.05) decrease of IgA and IgE, as compared with initial values.