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Войти в исследования The SIS NET ICU study: characteristics of patients with severe community acquired pneumonia admitted to Italian ICUs-a multicenter prospective observational study.
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Ippolito Mariachiara, Catalisano Giulia, Velardo Matteo, Campione Marina, Damiano Michael, Bocci Maria Grazia, Camilloni Barbara, Cocuzza Clementina, Comar Manola, De Robertis Edoardo, Fasciana Teresa Maria Assunta, Fumagalli Roberto, Giammanco Giovanni Maurizio, Girardis Massimo, Marchese Anna, Panascia Ettore, Pace Maria Caterina, di Villalba Cesira Palmeri, Patroniti Nicolò, Roman-Pognuz Erik, Raineri Santi Maurizio, Romagnoli Stefano, Spadaro Savino, Terragni Pierpaolo, Uzzau Sergio, Vaschetto Rosanna, Cortegiani Andrea, Giarratano Antonino, S I S-N E T I C U Study Group
Аннотация
METHODS: We conducted a prospective, observational, multicenter study. We included patients consecutively admitted to the ICUs of 13 participating centers during the study period for acute respiratory failure due to CAP. The study period spanned from January to November 2025. The analyses aimed to describe the epidemiological and clinical characteristics, diagnostic pathways, factors associated with ICU mortality, and type of respiratory support during the ICU stay.
RESULTS: We included a cohort of 150 patients with a mean age of 63 years and a male predominance (61%). The occurrence rate of CAP in the participating ICUs was 2.5%. Streptococcus pneumoniae, Haemophilus influenzae, Influenza A and Respiratory Syncytial Virus were the predominant isolated microorganisms. The average APACHE II score was 17 (SD 7.9) and the median SOFA score was 7 (SD 3.9). The comorbidity burden was substantial. A high proportion of patients was managed with non-invasive respiratory supports. Rapid microbiological testing methods were early adopted in 63% of patients, with substantial impact on antimicrobial therapy decisions. Each 10-year increase in age was associated with a 54% increase in the odds of death (aOR 1.54, 95% CI 1.06-2.35; p = 0.02) and immunosuppressed status was associated with higher odds of death (aOR 3.13, 95% CI 1.04-9.63; p = 0.04). Polymicrobial infection showed a trend towards higher mortality (aOR 2.47, 95% CI 0.94-6.89; p = 0.06), although this association did not reach conventional statistical significance.
CONCLUSIONS: Our study demonstrated the predominance of common pathogens as microbiological isolates in patients with severe CAP in Italy. Age, and immunosuppressed status were independently associated with a higher odds of mortality.