Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder: A Report of a Rare Case.

Primary signet-ring cell carcinoma (PSRCC) of the urinary bladder is a rare histological variant and is often diagnosed at an advanced stage. Here we are reporting a case of a 48-year-old male who presented to us with painless hematuria, which was associated with increased frequency of urination and a sensation of incomplete bladder emptying. On diagnostic evaluation, it was confirmed as PSRCC of the urinary bladder. The patient underwent radical cystectomy in view of recurrent disease and subsequently received radiation therapy with concurrent cisplatin. Follow-up after completion of treatment revealed the development of skeletal and penile metastases. The patient is currently 12 months post chemoradiation and was started on chemotherapy. This case highlights the aggressive clinical course of this rare malignancy and emphasizes the multimodality management and close follow-up.