STUDIES WITH MARKED ANTISERA. III. INTERCHANGE BETWEEN UNMARKED ANTIBODY AND I131-MARKED ANTIBODY IN COMBINATION WITH CELLULAR ANTIGENS.
Specific interchange takes place between 131I-marked antibody combined with cellular antigens and the free unmarked antiserum antibody in three systems studied: (A) bovine cells with (i) human infectious mononucleosis serum and (ii) rabbit anti-bovine serum and (B) human Rh D-positive cells with Rh incomplete anti-D serum. The rate of interchange is much slower than the initial combination of an unmarked antibody with an unoccupied antigenic site, and also is slower in the Rh incomplete system than in the other systems studied. Rabbit antibovine red cell antiserum partly interchanges with 131I
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