Литература по диагнозу
Q70 · Синдактилия

Hypervitaminosis A dysmelia in rats.

Limb defects were induced in the offspring of rats by giving 200,000-800,000 i.u. per kg. vitamin A on days 10-16 of their pregnancy. The malformations were symmetrical and there was no fore or hind limb predominance but fore limb lesions tended to be more severe. As severity increased there was progressive distoproximal suppression of digital rays commencing with digits 1 and 5 then extending to digits 2 and 3. Digit 4 was affected last. Syndactyly of soft tissues and bone was a part of the process and could produce single composite digits. Deletion of digits occurred and could result from pu