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Brain region volumes and their relationship with disability progression and cognitive function in primary progressive multiple sclerosis.

BACKGROUND AND PURPOSE: Evidence on regional changes resulting from neurodegenerative processes underlying primary progressive multiple sclerosis (PPMS) is still limited. We assessed brain region volumes and their relationship with disability progression and cognitive function in PPMS patients. METHODS: This was an MRI analysis of 43 patients from the prospective Understanding Primary Progressive Multiple Sclerosis (UPPMS) cohort study. MRI scans were performed within 3 months before enrollment and at month 12. RESULTS: Gray matter volume of declive and white matter volumes adjacent to left …

New applications for independent activities of daily living in measuring disability in multiple sclerosis.

BACKGROUND: Disability outcome measures in multiple sclerosis (MS) focus heavily on ambulation; however, limitations in performing everyday activities encompass another type of disability. OBJECTIVES: The aim of this study was to examine the ability of instrumental activities of daily living (IADL) scale to discriminate between different levels of disability and to predict disability progression. METHODS: The North American Research Committee on Multiple Sclerosis (NARCOMS) registry fall 2006 semi-annual survey asked participants to complete the RAND-12, Performance Scales, Patient Determine…

A new paraplegin mutation in a patient with primary progressive multiple sclerosis.

Primary progressive multiple sclerosis (PPMS) presents with clinical signs of slowly progressive long tract dysfunction that can overlap with neurodegenerative disorders, such as hereditary spastic paraplegia (HSP). Herein, we present two siblings in whom we have identified a novel mutation in the paraplegin (SPG7) gene. The proband, a 49-year-old woman, presented with a five-year history of progressive spastic paraparesis and ataxia. Brain MRI showed mild cerebellar atrophy. The genetic study revealed a homozygous mutation in the SPG7 gene, that led to the diagnosis of HSP. Four years previou…

Верона подтверждает оценку DAAE, инструмент для оценки риска развития клинических заболеваний у людей с множественным склерозом.

Счёт DAAE - это инструмент для оценки риска развития болезни пациента. Мы поставили перед собой цель утвердить этот инструмент с помощью внешних средств. МЕТОДЫ: Данные были собраны у клинической группы, которая лечилась в Центре MS в Вероне. Мы провели оценку двоичных прогнозов в отношении сбалансированных данных по конкретным случаям с использованием методов синтетического отбора меньшинств. Результаты: Включенные пациенты (n = 218) имели средний возраст (SD) и продолжительность болезни 36,8(11.0) и 6.5(6.6). Свыше 5,2(1,2) года 53 (24,3%) пациентов были преобразованы в вторичные прогрессивн

Prognostic significance of oligoclonal bands and their subtypes in relapsing-remitting multiple sclerosis.

OBJECTIVE: To investigate the long-term prognostic significance of cerebrospinal fluid oligoclonal band (OCB) positivity and its subtypes (Type 2 and Type 3) in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: This retrospective cohort included 2324 RRMS patients diagnosed using the 2017 McDonald criteria. All patients had documented OCB status and at least 2 years of clinical follow-up; a subset had 5-year data. Outcomes included Expanded Disability Status Scale (EDSS), annualised relapse rate (ARR), and conversion to secondary progressive MS (SPMS). Subgroup analysis co…

Glatiramer acetate for multiple sclerosis.

BACKGROUND: This is an updated Cochrane review of the previous version published (Cochrane Database of Systematic Reviews 2004 , Issue 1 . Art. No.: CD004678. DOI: 10.1002/14651858.CD004678)Previous studies have shown that glatiramer acetate (Copaxone (R)), a synthetic amino acid polymer is effective in experimental allergic encephalomyelitis (EAE), and improve the outcome of patients with multiple sclerosis (MS). OBJECTIVES: To verify the clinical efficacy of glatiramer acetate in the treatment of MS patients with relapsing remitting (RR) and progressive (P) course. SEARCH STRATEGY: We sear…

Patient-reported gradual worsening reveals progression beyond MS subtypes.

BACKGROUND: Gradual worsening in relapsing-remitting MS (RRMS) may precede the formal transition to secondary progressive MS (SPMS). We aimed to quantify self-reported gradual worsening, assess concordance with clinically recorded subtype, and identify baseline predictors of discordance. METHODS: We included 1640 participants with incident RRMS from a population-based study (2005-2019). A 2021 follow-up survey captured patient-reported gradual worsening. Clinical data, including Expanded Disability Status Scale (EDSS) scores and SPMS classification, were obtained from the Swedish MS registry.

Mitochondrial function of peripheral lymphocytes: role on multiple sclerosis clinical subtypes.

AIMS: Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease of unknown etiology, resulting in unmet therapeutic needs. Symptoms heterogeneity and incomplete mechanistic understanding hinder effective patient stratification. We aimed to evaluate the integrated peripheral immune response in established MS clinical subtypes, focusing on differences in mitochondrial function that might validate this stratification and further clarify MS etiology. MATERIALS AND METHODS: Mitochondrial activity of peripheral blood mononuclear cells (PBMCs) upon PHA-stimulation was analysed in MS pa…

Ocular pathology in multiple sclerosis: retinal atrophy and inflammation irrespective of disease duration.

There has been growing interest in the use of retinal imaging for tracking disease progression in multiple sclerosis. However, systematic and detailed pathological descriptions of retinal tissue in multiple sclerosis are lacking. Graded, histological evaluations on eyes from 82 patients with multiple sclerosis and 10 subjects with other neurological diseases, with immunohistochemistry on a subset, were performed and correlated with clinical and pathological findings. Multiple sclerosis cases demonstrated evidence of retinal atrophy and inflammation even in late-stage disease. Retinal ganglion …

The Development of the Combination Drug Leukovir® Tablets for the Treatment of Multiple Sclerosis: A Comprehensive Review.

The review is devoted to the development and study of the drug Leukovir® (cladribine+ ribavirin) and its use in the treatment of relapsing-remitting and secondary progressive forms of multiple sclerosis, a chronic neurodegenerative disease aiming the risk reduction of relapse and progression of a disability. In clinical trials Leukovir® has proved to be efficient by up to 56 weeks for the treatment of relapsing-remitting and secondary progressive forms of multiple sclerosis. The drug is registered in the Republic of Belarus. The efficacy, safety and tolerability profile of the drug Leukovir® s…

[Prevalence and impact of comorbidities in patients with multiple sclerosis].

INTRODUCTION: Multiple sclerosis is a chronic, inflammatory and degenerative disease of the central nervous system. In most cases it is characterised by the recurring focal neurological deficit, which may become progressive over time. Given the chronic nature of the disease, patients may present with additional diseases (comorbidities), which affect the natural history of the disease and its treatment in different ways. AIM: To summarise the available evidence regarding the influence of comorbidities on the natural history of multiple sclerosis. DEVELOPMENT: Patients with multiple sclerosis …

Dura mater enhancement on 3T MRI is associated with cortical lesion burden in multiple sclerosis.

BACKGROUND: Post-contrast FLAIR MRI can demonstrate meningeal signal enhancement in people with multiple sclerosis (pwMS), including enhancement along the leptomeninges and dura mater. Although these enhancement patterns have been variably interpreted as reflecting inflammatory processes, their biological specificity and relationship to cortical lesion pathology remain uncertain. OBJECTIVE: To evaluate the association between cortical lesion burden and distinct patterns of meningeal enhancement (ME), including dura mater enhancement (DME), leptomeningeal enhancement (LME), and meningeal periv…

Нейродегенерация коррелирует с повреждениями, связанными с железом, и воспалением лептомеинов в многочисленных клинических подтипах склероза.

ЦЕЛЬ: Цель этого исследования заключалась в изучении существенных последствий различных видов повреждений, которые были оценены QSM (каличественная-приемлемость), а также лептоминговой контрастности в группе пациентов, страдающих релапсирующими и первичными прогрессивными (ПП) MS, и в оценке их связи с клиническими нарушениями и измерением МРТ структурных повреждений головного мозга. МЕТОДЫ: Были выявлены и количественно определены различные виды повреждений белой материи с использованием QSM в 24 РОРМ и 15 ИЦУП (СУП)11 - пациенты с последующим МРТ). Оценка степени контрастности (LMCE; foci) 3

Совпадение в полном тексте источника
… Introduction Multiple sclerosis (MS) is a chronic disabling neurological condition affecting the CNS, which most commonly becomes clinically evident during early adult life. … EDSS = Expanded Disability Status Scale; MS = multiple sclerosis; QSM = quantitative susceptibility mapping; NAWM, normal appearing white matter E. …

The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis.

Multiple sclerosis is one of the most common causes of chronic neurological disability beginning in early to middle adult life. Multiple sclerosis is idiopathic in nature, yet increasing correlative evidence supports a strong association between one's genetic predisposition, the environment and the immune system. Symptoms of multiple sclerosis have primarily been shown to result from a disruption in the integrity of myelinated tracts within the white matter of the central nervous system. However, recent research has also highlighted the hitherto underappreciated involvement of gray matter in m…

Human calprotectin as a novel biomarker in multiple sclerosis: Can it differentiate disease stages?

This study aims to investigate the relationship between serum calprotectin levels and different stages of multiple sclerosis (MS). This study was designed as a prospective, cross-sectional case-control study. A total of 98 patients diagnosed with relapsing-remitting MS and secondary progressive MS according to the 2017 McDonald criteria, along with 40 control patients whose human calprotectin levels were measured, were included in the study. The average age and human calprotectin levels in the patient group were found to be higher compared to the control group (P = .013 and P < .001, respectiv…

Choroid Plexus Enlargement in Multiple Sclerosis Correlates with Cortical and Phase Rim Lesions on 7T MRI and Predicts Progression Independent of Relapse Activity.

BACKGROUND AND PURPOSE: In multiple sclerosis, the choroid plexus is thought to promote and sustain the disease immunopathologic inflammatory process. However, its association with cortical pathology and disease progression is still uncertain. We aimed to characterize choroid plexus enlargement and evolution in MS and its relationship with imaging markers of compartmentalized inflammation and clinical outcome. MATERIALS AND METHODS: One hundred patients with MS (74 relapsing-remitting [RRMS]; 26 secondary-progressive MS [SPMS] and 41 matched healthy controls (HC) underwent 3T MRI to measure b…

Relapse-associated versus relapse-independent progression determines disability trajectories in multiple sclerosis beyond EDSS 3.0.

BACKGROUND: Multiple sclerosis (MS) exhibits a two-stage disability progression model in which early inflammatory activity influences the timing of moderate disability (EDSS 3.0), whereas subsequent progression is largely relapse-independent. It remains unclear whether this paradigm persists in the era of high-efficacy disease-modifying therapies (DMTs). OBJECTIVES: To assess whether attainment of sustained EDSS 3.0 via relapse-associated worsening (RAW) or progression independent of relapse activity (PIRA) influences subsequent disability accumulation and to evaluate the impact of DMTs on lo…

Регулирование эндосомного комплекса сортировки III связано с нейродегенерацией в прогрессивном множественном склерозе.

Множественный склероз (MS) — хроническое нервно-воспалительное заболевание, которое переходит в стадию необратимого неврологического упадка и широкомасштабного нейродегенерации. Некроптоз — регулируемая форма клеточной смерти, вызванной главным образом некрозом опухоли (TNF), — был связан с нейронной потерей в прогрессивных MS. Как известно, эндосомный сортинговый комплекс, необходимый для транспортных механизмов (ESCRT), который необходим для ремонта плазменной мембраны и незаконного оборота везикла, противодействует некроптозу в ненейральных клетках. В этом исследовании мы изучили, способств

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic neuroinflammatory disease that progresses to a stage marked by irreversible neurological decline and widespread neurodegeneration. Necroptosis, a regulated form of cell death primarily triggered by tumor necrosis factor (TNF), has been implicated in neuronal loss in progressive MS. The Endosomal Sorting Complex Required f…

Нет связи между когнитивным расстройством, физической инвалидностью и серумными биомаркерами в коорте прогрессивных пациентов с множественным склерозом.

Несмотря на значительные усилия, по-прежнему существует потребность в выявлении диагностических средств, которые позволили бы быстро и надежно обнаруживать прогрессирующую стадию множественного склероза (MS) и помогли бы в мониторинге курса заболевания и/или воздействия лечения. Цель этого перспективного исследования в группе людей с прогрессивным MS заключалась в том, чтобы определить, могут ли изменения в уровнях отдельных биомаркеров сыворотки и когнитивной функции предсказывать прогрессирование заболеваний и, следовательно, совершенствовать процесс принятия решений при оценке пациентов с M

Совпадение в аннотации оригинала
Despite significant efforts, there is still an existing need to identify diagnostic tools that would enable fast and reliable detection of the progressive stage of multiple sclerosis (MS) and help in monitoring the disease course and/or treatment effects. The aim of this prospective study in a group of people with progressive MS was to determine whether chan…

Первичный прогрессивный множественный склероз: новые терапевтические подходы.

ЦЕЛЬ И ЗАДАЧА: Первичный прогрессивный множественный склероз (ППМС) представляет собой клинически иную форму MS, которая вызывает постепенное и необратимое неврологическое расстройство вследствие возникновения симптомов без рецидивов или ремиссий. С учетом того, что средний возраст наступает в 37-43 года, СУПЗ затрагивает 10-15% пациентов, страдающих НР, и вызывает особые проблемы с диагностикой и лечением. Проблемы с мобильностью, постоянная боль, сенсорные расстройства, когнитивные недостатки, а также проблемы с кишечником и мочевым пузырем с течением времени обостряются. Нейроимация показыв

Совпадение в аннотации оригинала
BACKGROUND AND PURPOSE: Primary progressive multiple sclerosis (PPMS) is a clinically different form of MS that causes gradual and irreversible neurological impairment from symptom onset without relapses or remissions. With a mean onset age of 37-43 years, PPMS affects 10%-15% of MS patients and presents distinct diagnostic and treatment issues. Mobility iss…