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Shaping the physical world to our ends through the left PF technical-cognition area.

Our propensity to materiality, which consists in using, making, creating, and passing on technologies, has enabled us to shape the physical world according to our ends. To explain this proclivity, scientists have calibrated their lens to either low-level skills such as motor cognition or high-level skills such as language or social cognition. Yet, little has been said about the intermediate-level cognitive processes that are directly involved in mastering this materiality, that is, technical cognition. We aim to focus on this intermediate level for providing new insights into the neurocognitiv…

Impact of chronic alcohol and stress on mid-life cognition and locus coeruleus integrity.

BACKGROUND: Excessive alcohol consumption and stress are associated with structural and functional alterations in the brain and impaired cognition. However, the persistence of long-term neural impacts after alcohol and stress are less understood. This study investigated midlife cognition and neuropathological changes following a history of alcohol and stress exposure. METHODS: C57BL/6J mice acclimated to ethanol drinking (15% v/v) before exposure to four cycles of alternating chronic intermittent ethanol (CIE) vapor exposure and repeated forced swim stress (FSS), with control groups exposed t…

Cognition during ictal and interictal migraine phases: A pilot study using ecological momentary assessment.

OBJECTIVE: The present study aimed to evaluate cognitive functioning during ictal and interictal phases of the migraine attack using smart-p … These methods further characterize the cognitive burden of migraine and could be extended to assess cognition in the prodrome and postdrome, as well as assess the cognitive benefits of acute and preventive treatment in randomized trials.

Effects of naturalistic doses of cannabis edibles on cognition and association with blood THC.

BACKGROUND: Smoked cannabis is known to have effects on cognitive function. The use of edibles is on the rise yet there are few studies of the effects of edibles on cognitive function. Further, most studies of cannabis used fixed laboratory doses which may not capture some of the nuances of more naturalistic doses. Delta-9-tetrahydrocannabinol (THC) is the psychoactive component of cannabis yet the relationship of blood THC to cognitive performance is unclear. METHODS: In the present observational study participants (n = 22) were invited to the lab to use their regular legally sourced cannabi

Impact of White Matter Hyperintensities on Nonverbal Cognition Through Structural Disconnections in Poststroke Aphasia.

BACKGROUND: Nonverbal cognitive deficits in poststroke aphasia remain poorly understood. They may result from direct stroke damage or discon … ronic left hemisphere ischemic or hemorrhagic stroke were enrolled between 2012 and 2021. Nonverbal cognition was assessed using the Matrix Subtest of the Wechsler Adult Intelligence Scale Version IV, the Pyramids and Palm Trees Test, and the Kissing and Dancing Test. Stroke lesions and WMH masks were derived from structural magnetic resonance imaging scans …

A comparison of drugs targeting the renin-angiotensin system and global cognition in aging.

BackgroundHypertension (HTN) is a major risk factor for Alzheimer's disease (AD) and related dementias. Renin-angiotensin system (RAS) medications, including angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs), have been proposed to mitigate cognitive decline, but evidence remains inconsistent.ObjectiveCompare global cognition over time among ARB, ACEI, and non-RAS drug users.MethodsData from the Rush Memory and Aging Project (1997-2006) included 2019 participants. Global cognition was assessed using a composite z-score of 19 cognitive tests. Participan…

Seizure freedom in pediatric juvenile myoclonic epilepsy: The roles of cognition, chronodependency, and EEG.

OBJECTIVE: To identify clinical, chronobiological, and electroencephalographic (EEG) predictors of seizure freedom in pediatric patients with juvenile myoclonic epilepsy (JME), and to evaluate the prognostic utility of both classic and novel markers in a real-world setting. METHODS: We conducted a retrospective cohort study of 71 pediatric JME patients (mean age at diagnosis 16.1 ± 1.05 years; 76.1 % female) diagnosed at a single tertiary center between January 2023 and January 2025. Data collected included demographic variables, seizure characteristics, academic performance, comorbidities, a

The effect of lateralization bias of pain on pain, anxiety and cognition in mice.

The transmission of pain signals through the spinal cord can cause structural and functional changes in the brain, which may contribute to d … rious behavioral tests. We evaluated their behaviors in the open field (OF), Y-maze, novel object recognition, and fear conditioning tests, and compared their performance to that of sham mice. Compared with sham mice, SNI mice manifested mechanical allodynia. In the OF test, SNI-L mice showed an increased anxiety-like profile compared to the other groups. B …

Phenotypic variability and preserved cognition in a family with KCNA2-related developmental epileptic encephalopathy.

Developmental and epileptic encephalopathy type 32 (DEE32) is a severe neurological disorder caused by pathogenic variants in the KCNA2 gene … ally controlled but later recurring after medication weaning. His WPPSI assessment indicated normal cognition with a standard score of 113, and his mild speech delay resolved. Patient 2, a female, had a normal brain MRI and normal WPPSI evaluation (standard score of 111), with well-controlled seizures on zonisamide. The father had childhood-onset epilepsy p …

Association between childhood war exposure and late-life cognition and incident MCI and dementia.

OBJECTIVE: While early-life adverse experiences have been linked to late-life cognitive decline, few studies have explored war exposure. Paradoxically, one study even indicated a late-life cognitive advantage of early-childhood war exposure. In the present study, we explored these associations. METHODS: We examined older adults exposed to World War II (1940-1944; n = 1179) and the subsequent Civil war (1946-1949; n = 962) in Greece during early and middle childhood with a comprehensive neuropsychological assessment and for ApoE-ε allele status, including demographic information and medical hi

A cross-sectional study on long covid, cognition and neurasthenia-one year post covid.

INTRODUCTION: The COVID-19 pandemic has led to long-term health effects in some patients, known as long COVID. This study aimed to delineate … een post-COVID symptoms and chronic low-grade inflammation. These findings highlight the need for recognition and management of long-term COVID-19 effects in public health policies.

Social cognition in basal ganglia pathologies: Theory of Mind in Huntington's and Parkinson's diseases.

Theory of Mind (ToM) is the ability to predict the behaviour of others by inferring their cognitive and affective states. The literature suggests that different neural substrates within the basal ganglia are involved in the affective (ventral striatum) and cognitive (dorsal striatum) components of ToM. We investigated ToM dysfunction in two different basal ganglia pathologies, Huntington's disease (HD) and Parkinson's disease (PD), in their early stages. Indeed, a different progression of neurodegeneration from the dorsal striatum to the ventral striatum is described in the two diseases. We al

Радиомикальный подход к клиническому МРТ проясняет связь между Таламом и Когницией в множестве склерозов.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛЬ: Радиомика излучает изображения, которые, возможно, не поддаются обнаружению в ходе обычного объемного анализа. Учитывая их роль в множестве склероза (MS), мы применили радиомедики к таламическим ядрам и изучили их связи с когнитивными характеристиками. МЕТОДЫ: В общей сложности 601 человек были включены (342 человека с MS [PwMS] из двух когорт и 259 лиц, осуществляющих контроль за состоянием здоровья. Радиомикальные функции (RF) и тома были получены из всего таламуса, пяти таламических ядер, и мутамен был разделен на трехмерные изображения Т1. Когнитивные характер

Изучение субдоменов и прогнозов социальной когниции при многоразовом склерозе: перекрестное исследование.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛЬ: Социальное понимание (СК) все шире признается в качестве ключевой когнитивной области, затронутой множественным склерозом (МС), однако его поддомы и клинические коррелы по-прежнему недостаточно изучены. Цель этого исследования заключалась в оценке различных поддомов СК и выявлении их когнитивных, эмоциональных и демографических прогнозов у людей с MS (PwMS). МЕТОДЫ: Это перекрестное исследование включало 93 ПМС и 34 НС. Оценки включали в себя: " Чтение разума в глазах " (РМЕТ) для распознавания эмоций, " Тест троллей " (TMT) на исполнительную ф

Совпадение в аннотации оригинала
BACKGROUND AND PURPOSE: Social cognition (SC) is increasingly recognized as a key cognitive domain affected in multiple sclerosis (MS), yet its sub-domains and clinical correlates remain underexplored. This study aimed to assess different SC sub-domains and identify their cognitive, emotional, and demographic predictors in people with MS (pwMS). METHODS: Th…

Возрастные различия в структуре хороидового слекса связаны с изменениями в когнитивной целостности.

РЫНК: Хороидный слексус (CP) играет важнейшую роль в поддержании гомеостазиза центральной нервной системы (CNS), производстве цереброспинной жидкости и регулировании поступления конкретных веществ в ЦНК из крови. Дефункция ХП была связана с различными неврологическими и психическими расстройствами, включая болезнь Альцгеймера, болезнь Паркинсона и множественный склероз.МЕТОДЫ: В настоящем исследовании изучается взаимосвязь между структурной целостностью ХП и когнитивным снижением нормативных показателей старения с использованием структурных и передовых методов магнитного резонансного изображен

Корреляция " Когниции с инвалидностью " и Физическая результативность у пациентов с повторной эмиссией MS.

У пациентов с множественным склерозом (МС) широко распространено когнитивное расстройство. Физическая активность явно связана с когнитивными характеристиками, и ряд исследований продемонстрировали важность регулярного тестирования на когнитивацию, однако в клинической практике такие испытания все еще не проводятся на регулярной основе. ЦЕЛЬ: Данное исследование было направлено на изучение взаимосвязи между когнитивом, инвалидностью и физическими показателями у пациентов с повторными выбросами MS (RRMS). МЕТОДЫ: Всего 41 :: пациенты, имеющие RRMS с повышенным уровнем инвалидности (EDSS) 0-5.5 и

Совпадение в аннотации оригинала
BACKGROUND: Cognitive impairment is common in patients with multiple sclerosis (MS). Physical activity is clearly linked to cognitive performance, and several studies have shown the importance of regular cognition testing, but such testing is still not routinely performed in clinical practice. OBJECTIVE: This study aimed to investigate the association betwe…

A tutorial on fitting joint models of M/EEG and behavior to understand cognition.

We present motivation and practical steps necessary to find parameter estimates of joint models of behavior and neural electrophysiological data. This tutorial is written for researchers wishing to build joint models of human behavior and scalp and intracranial electroencephalographic (EEG) or magnetoencephalographic (MEG) data, and more specifically those researchers who seek to understand human cognition. Although these techniques could easily be applied to animal models, the focus of this tutorial is on human participants. Joint modeling of M/EEG and behavior requires some knowledge of exis…

Digital assessment of cognition in neurodegenerative disease: a data driven approach leveraging artificial intelligence.

INTRODUCTION: A rapid and reliable neuropsychological protocol is essential for the efficient assessment of neurocognitive constructs relate … ed through paper-and-pencil tests (i.e., serial list learning, immediate and delayed free recall, recognition hits, percent correct serial order backward digit span, and "animal" fluency output). Additionally, the protocol includes variables that quantify errors and detail the processes used in administering the tests. It also features two separate, norm-re …

An investigation of allied health and medical clinicians' viewpoint on prosthetic rehabilitation and cognition.

PURPOSE: To explore the factors that influence clinicians (occupational therapists, physiotherapists, vascular surgeons, and rehabilitation medicine physicians) when prescribing prosthetic rehabilitation. Additionally, the study aimed to gain insight into clinicians' perspectives regarding the role of patient cognition in prosthetic rehabilitation. MATERIALS AND METHODS: This research constitutes one segment of a broader action research study which was undertaken in 2022. A total of thirty-four key clinicians involved in the amputation and prosthetic rehabilitation pathway within a local heal…

Multisensory training improves the development of spatial cognition after sight restoration from congenital cataracts.

Spatial cognition and mobility are typically impaired in congenitally blind individuals, as vision usually calibrates space perception by providing the most accurate distal spatial cues. We have previously shown that sight restoration from congenital bilateral cataracts guides the development of more accurate space perception, even when cataract removal occurs years after birth. However, late cataract-treated individuals do not usually reach the performance levels of the typically sighted population. Here, we developed a brief multisensory training that associated audiovisual feedback with bod…