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The effects of cognitive behavioral therapy-based digital therapeutic intervention on patients with alcohol use disorder.

INTRODUCTION: This study investigated the effectiveness of a digital therapeutic intervention for individuals with alcohol use problems. Dig … provided with a mobile application that included a diary feature for tracking alcohol consumption, cravings, and mood. Assessments were conducted at baseline, mid-treatment (week 4), and post-treatment (week 12) to evaluate risky drinking, craving, readiness for change, depression, anxiety, and alcohol-related symptoms. RESULTS: The primary outcome, abs …

[Topic study on smoking cessation motivation and relapse triggers of hypertensive patients in the community based on the bi-term topic model].

OBJECTIVE: To explore the motivations for quitting smoking and the factors leading to relapse among smokers who have quit. METHODS: Data fr … , family persuasion, economic pressure, and advice from doctors. Relapse triggers included nicotine cravings, socializing with smokers, being offered cigarettes, and attending gatherings. (3) Time trend of topic heat: the topics of "nicotine cravings" and "socializing with smokers" showed an increasing trend, while the topic of "gatherings" showed a decre …

Tai Chi Easy for Opioid Use Disorder: Pilot Feasibility Outcomes and Lessons Learned.

Background: Opioid use disorder (OUD) remains a global crisis, with chronic pain (CP), anxiety, and opioid cravings contributing to treatment discontinuation and return to opioid use. Despite the effectiveness of medications for OUD (MOUD) such as buprenorphine and methadone, they are underutilized, with nearly 50% of individuals discontinuing prematurely or returning to opioid use. Mind-body therapies (e.g., mindfulness, acupuncture, Tai Chi) have shown promise in reducing stress, drug cravings, and pain while improving well-being. However, Tai Chi has not been systematically tested for indiv…

Однолетний срок последствий лечения, основанного на принятии, гиперсексуальности.

Гиперсексуальность связана со значительными психологическими расстройствами и рисками для здоровья, однако лишь в немногих исследованиях были изучены долгосрочные последствия психологического вмешательства. one- годовые последующие результаты краткого, индивидуального вмешательства в терапию принятия и принятия обязательств (АКТ) для пациентов с клинически значимой гиперсексуальностью. eight- Сессионный протокол АСТ оценивался на этапе предварительного лечения, после лечения и на этапе 3-month и 1-year - последующие мероприятия с использованием стандартизованных самоотчетных мер. Статистическа

Совпадение в аннотации оригинала
BackgroundHypersexuality is associated with significant psychological distress and health risks, yet few studies have examined the long-term … cobson and Truax method to evaluate individual-level change.ResultsReductions in hypersexuality and craving interference, as well as increases in values-consistent behavior and perceived control over craving, were maintained at the one-year follow-up. Psychological inflexibility, which had not significantly changed immediately after treatment, showed sign …

Light Therapy Alleviates Addiction-Related Symptoms and Reshapes Habenula and Midbrain Pathways.

The treatment of internet gaming disorder (IGD) poses a significant challenge. Light therapy has demonstrated efficacy in preventing cocaine … of cognitive training group, with greater reductions in addiction severity, weekly gaming duration, craving, and withdrawal symptoms than the placebo group. Longitudinal fMRI shows reduced activation in right inferior orbitofrontal cortex (iOFC), left inferior frontal gyrus, and right insula. Using habenula, ventral tegmental area (VTA), and dorsal raphe …

Dual hypocretin receptor antagonism reduces oxycodone seeking and attenuates aberrant dopamine transporter function during abstinence.

A major barrier in the treatment of opioid use disorder is persistent drug craving during abstinence. While opioid-based medications have been used to treat opioid use disorder for decades, there is an urgent need for novel, non-opioid-based pharmacotherapies. The hypocretin/orexin (hypocretin) system is a promising target for treating opioid use disorder due to its influence on motivation for drugs of abuse through actions on dopamine transmission. We recently showed that intermittent access to oxycodone promoted sustained oxycodone seeking and alterations in dopamine transmission during abst…

Neurotransmitter receptor gene expression patterns associated with reward-related neural representations.

The neural representation of reward is underpinned by neurotransmitter systems; however, current human neuroimaging techniques cannot assess … receptor expression. Similar positive correlations with serotonin receptor 2 A were observed in the craving maps. Principal component regression provided complementary evidence, with both monetary reward and craving maps showing significant associations with components characterized by NOP receptor loadings. These findings from multiple analytical approac …

Effects of exercise intervention on tobacco dependence: a meta-analysis.

INTRODUCTION: Smoking poses a significant threat to global human health, making smoking cessation a controllable means of preventing mortali … ween the exercise and control groups. However, acute exercise was associated with increased tobacco craving (desire and intensity) and more pronounced withdrawal symptoms. DISCUSSION: Acute aerobic exercise can significantly reduce craving and withdrawal symptoms among individuals attempting to quit smoking, demonstrating a certain role in smoking cessat …

A case series examining the efficacy of gabapentin as a substitution therapy for the treatment of pregabalin use disorder.

Background: Gabapentinoids are ligands of a brain calcium channel, which are approved for different indications, including epilepsy, neuropathic pain, or generalized anxiety disorder. Among gabapentinoids, pregabalin has been increasingly associated with a risk of pregabalin use disorder (PUD). To date, there is no recommended medical treatment for PUD. However, gabapentin, which has a lower abuse potential, could be used as a substitution therapy to reduce pregabalin withdrawal and craving.Objectives: To report on the experimental use of high dose of gabapentin among those with PUD.Methods: C…

Cocaine-Induced Microglial Impairment and Its Rehabilitation by PLX-PAD Cell Therapy.

Chronic cocaine use triggers inflammatory and oxidative processes in the central nervous system, resulting in impaired microglia. Mesenchymal stem cells, known for their immunomodulatory properties, have shown promise in reducing inflammation and enhancing neuronal survival. The study employed the cocaine self-administration model, focusing on ionized calcium-binding adaptor protein 1 (Iba-1) and cell morphology as markers for microglial impairment and PLX-PAD cells as a treatment for attenuating cocaine craving. The results revealed an addiction-stage and region-specific impairment in microgl…

Insular volumetry in severe alcohol use disorder and Korsakoff's syndrome through an anatomical parcellation: Let us go back to basics.

Functional neuroimaging has demonstrated the key role played by the insula in severe alcohol use disorder (sAUD), notably through its involvement in craving and body signals processing. However, the anatomical counterpart of these functional modifications in sAUD patients with and without neurological complications remains largely unexplored, especially using state-of-the-art parcellation tools. We thus compared the grey matter volume of insular subregions (form anterior to posterior: anterior inferior cortex, anterior short gyrus, middle short gyrus, posterior short gyrus, anterior long gyrus…

Adult Attention-Deficit Hyperactivity Disorder/Substance Use Disorder Dual Disorder Patients: A Dual Disorder Unit Point of View.

Substance Use Disorders (SUDs) are often associated with Attention-Deficit Hyperactivity Disorder (ADHD) in adult populations due to multiple neurobiological, genetic, and psychosocial risk factors. This chapter provides a picture of the clinical aspects of adults with both ADHD and SUDs at treatment entry into a Dual Disorder Unit introducing the concept of different types of craving that may lead to substance use and abuse. At treatment entry, the presence of different comorbid SUD clusters, characterized by either stimulants/alcohol or by the use of cannabinoids, has not been shown to influ…

Transcranial Magnetic Stimulation for the Treatment of Cocaine Addiction: A Systematic Review.

Long-term cocaine use is associated with cognitive deficits and neuro-psychiatric pathologies. Repetitive transcranial magnetic stimulation … iveness. Significant results of the efficacy of TMS have been observed in terms of the reduction of craving to consume and the number of doses consumed. No serious adverse effects have been observed. Despite the low quality of the studies, the first results were observed in terms of reduction of cocaine use and craving. In any case, this effect is conside …

Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence.

Patients with opioid use disorder experience high rates of relapse during recovery, despite successful completion of rehabilitation programs … contributed to drug-seeking after abstinence, regardless of abstinence length. Incubation of opioid craving at higher dosages paired with discrete drug cues was not dependent on drug intake. Thus, interactions between drug cues and drug dosage uniquely determined conditions permissible for incubation of heroin craving. Understanding factors that contribut …

No effect of repetitive tDCS on daily smoking behaviour in light smokers: A placebo controlled EMA study.

INTRODUCTION: The effectiveness of repetitive transcranial Direct Current Stimulation (tDCS) on reducing smoking behaviour has been studied … ree different days in one week. They were asked to keep track of their daily cigarette consumption, craving and affect in an application on their mobile phones for three months starting one week before the first tDCS session. RESULTS: Number of smoked cigarettes a day progressively decreased up to one week after the last tDCS session in both conditions. …

Baclofen modulates cardiovascular responses to appetitive cues in treatment-seeking alcohol use disorder individuals.

OBJECTIVE: To assess whether baclofen-treated alcohol dependent participants show different subjective and psychophysiological responses to … and alcohol beverage cues were presented, with subsequent recovery periods, and subjective alcohol craving and psychophysiological indices (skin conductance; cardiovascular measures: heart rate, high-frequency heart rate variability) were recorded. RESULTS: High-dose baclofen-treated participants showed both overall cue reactivity to water and alcohol c …

Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction.

Cocaine addiction is characterized by overwhelming craving for the substance, which drives its escalating use despite adverse consequences. Animal models suggest a disrupted glutamate homeostasis in the nucleus accumbens to underlie addiction-like behavior. After chronic administration of cocaine, rodents show decreased levels of accumbal glutamate, whereas drug-seeking reinstatement is associated with enhanced glutamatergic transmission. However, due to technical obstacles, the role of disturbed glutamate homeostasis for cocaine addiction in humans remains only partially understood, and accor…

A further assessment of a role for Toll-like receptor 4 in the reinforcing and reinstating effects of opioids.

The Toll-like receptor 4 (TLR4) antagonists, (+)-naloxone and (+)-naltrexone, have been reported to decrease self-administration of opioids … TLR4 antagonism in opioid self-administration and to explore its effects in a preclinical model of craving/relapse. The TLR4 antagonist (+)-naltrexone decreased responding in rats trained to self-administer the µ-opioid receptor agonist remifentanil, but with a potency that was not significantly different from that observed in another group of subjects i …

Feedback-Based Treatments for Eating Disorders and Related Symptoms: A Systematic Review of the Literature.

The effectiveness of biofeedback and neurofeedback has been investigated in a range of psychiatric disorders. However, to date, there are few studies on the clinical usefulness of feedback-based techniques for eating disorders (EDs) and EDs-related symptoms (e.g., food craving). A systematic search of PubMed, Scopus and PsychINFO identified 162 articles. Among these, thirteen studies exploring the therapeutic use of biofeedback and neurofeedback in EDs or EDs-related symptoms were included. Biofeedback and neurofeedback were implemented respectively in five and eight of all reviewed articles. …

A cholecystokinin B receptor antagonist and cocaine interaction, phase I study.

AIMS: RPR 102681, a cholecystokinin-B antagonist, increased dopamine (DA) release and reduced cocaine self-administration in animals. This p … zoylecgonine and showed no intrinsic abuse liability. There was a trend toward reduction of cocaine craving scores. In contrast to animal studies, RPR 102681 significantly increased the binding potential of [11 C]raclopride in the ventral striatum (t test, P < .001) and caudate nucleus (t test, P < .0001) in a small subset of patients, suggesting that it …