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Promising Activities of Marine Natural Products against Hematopoietic Malignancies.

According to the WHO classification of tumors, more than 150 typologies of hematopoietic and lymphoid tumors exist, and most of them remain incurable diseases that require innovative approaches to improve therapeutic outcome and avoid side effects. Marine organisms represent a reservoir of novel bioactive metabolites, but they are still less studied compared to their terrestrial counterparts. This review is focused on marine natural products with anticancer activity against hematological tumors, highlighting recent advances and possible perspectives. Until now, there are five commercially avai

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… They concluded that different anti-leukemic compounds may be produced by cyanobacteria and further chemical analyses may help to characterize their structures. … As reported in this review, most of the active compounds against hematopoietic tumors have been isolated from sponges, cyanobacteria, and microalgae. …

Ecological and toxicological effects of inorganic nitrogen pollution in aquatic ecosystems: A global assessment.

We provide a global assessment, with detailed multi-scale data, of the ecological and toxicological effects generated by inorganic nitrogen … e occurrence of toxic algae can significantly contribute to the extensive kills of aquatic animals. Cyanobacteria, dinoflagellates and diatoms appear to be major responsible that may be stimulated by inorganic nitrogen pollution. Among the different inorganic nitrogenous compounds (NH4+, NH3, NO2-, HNO2NO3-) that aquatic animals can take up directly from the am …

Advances in delivery methods of Arthrospira platensis (spirulina) for enhanced therapeutic outcomes.

Arthrospira platensis (A. platensis) aqueous extract has massive amounts of natural products that can be used as future drugs, such as C-phycocyanin, allophycocyanin, etc. This extract was chosen because of its high adaptability, which reflects its resolute genetic composition. The proactive roles of cyanobacteria, particularly in the medical field, have been discussed in this review, including the history, previous food and drug administration (FDA) reports, health benefits and the various dose-dependent therapeutic functions that A. platensis possesses, including its role in fighting against…

Biotechnological Innovations from Ocean: Transpiring Role of Marine Drugs in Management of Chronic Disorders.

Marine drugs are abundant in number, comprise of a diverse range of structures with corresponding mechanisms of action, and hold promise for the discovery of new and better treatment approaches for the management of several chronic diseases. There are huge reserves of natural marine biological compounds, as 70 percent of the Earth is covered with oceans, indicating a diversity of chemical entities on the planet. The marine ecosystems are a rich source of bioactive products and have been explored for lead drug molecules that have proven to be novel therapeutic targets. Over the last 70 years, m

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… In addition, to the antidiabetic activity of bacteria, cyanobacteria, and actinomycetes, marine fungi have also been screened to assess whether they might have antidiabetic action. … (Cyanobacteria), a Pantropical Marine Species with Biomedical Relevance. J. Phycol. 2015;51:670–681. doi: 10.1111/jpy.12309. 96. Salvador-Reyes L.A., Engene N., Paul V.J., Luesch H. …

Unlocking the Therapeutic Potential of Algae-Derived Compounds in Hematological Malignancies.

Algae are a rich source of bioactive compounds that have a wide range of beneficial effects on human health and can show significant potential in the treatment of hematological malignancies such as leukemia, lymphoma, and multiple myeloma. These diseases often pose a therapeutic challenge despite recent advances in treatment (e.g., the use of immunomodulatory drugs, proteasome inhibitors, CD38 monoclonal antibodies, stem cell transplant, and targeted therapy). A considerable number of patients experience relapses or resistance to the applied therapies. Algal compounds, alone or in combination

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… Scytonemin, a photoprotective pigment isolated from cyanobacteria, has been identified as a strong inhibitor of polo-like kinase 1 (PLK1), an important cell cycle regulator. … Aurilides, another class of depsipeptides mainly found in cyanobacteria (e.g., Lyngbya majuscula ), also showed cytotoxicity against various leukemia cell lines including HL-60, K562, MOLT-4, RPMI-8226, and SR [ 51 , 116 , 117 ]. …

Обнаружить важную роль гута микробиота и диета в многоразовом склерозе.

Множественный склероз (MS) — хроническое воспалительное заболевание центральной нервной системы (CNS), характеризующееся нейродегенерацией, повреждением аксона, обезвоживанием и воспалением. В последнее время кишечный дисбиоз связан с MS и другими аутоиммунными условиями. А именно, кишечная микробиота играет жизненно важную роль в регулировании иммунной функции, оказывая влияние на развитие иммунных клеток, производство цитокина и целостность кишечника. В то время как сбалансированная микробиота способствует иммунной терпимости, дисбиоз нарушает иммунное регулирование, наносит ущерб проницаемо

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… The human gut microbiota is dominated by Firmicutes and Bacteroidetes , with smaller proportions of other bacterial phyla such as Proteobacteria , Verrucomicrobia , Actinobacteria , Fusobacteria , and Cyanobacteria . GI, gastrointestinal tract. Adopted from [ 7 ]. Created in BioRender. … There are also more than 50 bacterial phyla that have been described to date, including Proteobacteria , Verrucomicrobia , Actinobacteria , Fusobacteria , and Cyanobacteria , that are present in trace amounts. …

Advanced Technologies for Large Scale Supply of Marine Drugs.

Marine organisms represent a source of unique chemical entities with valuable biomedical potentialities, broad diversity, and complexity. It is essential to ensure a reliable and sustainable supply of marine natural products (MNPs) for their translation into commercial drugs and other valuable products. From a structural point of view and with few exceptions, MNPs of pharmaceutical importance derive from the so-called secondary metabolism of marine organisms. When production strategies rely on marine macroorganisms, harvesting or culturing coupled with extraction procedures frequently remain t

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… There has been a decreasing trend in the reporting of metabolites from cyanobacteria, mangrove-associated fungi, and algae, while reports of sponge- and cnidarian-derived MNPs have shown an increase [ 11 ]. … These compounds can be obtained by cyanobacteria living within the host or expressed from microbial genes that have been integrated into the host sponge. …

Marine Natural Products with Activities against Prostate Cancer: Recent Discoveries.

Prostate cancer is the most common cancer in men, with over 52,000 new cases diagnosed every year. Diagnostics and early treatment are potentially hindered by variations in screening protocols, still largely reliant on serum levels of acid phosphatase and prostate-specific antigen, with tumour diagnosis and grading relying on histopathological examination. Current treatment interventions vary in terms of efficacy, cost and severity of side effects, and relapse can be aggressive and resistant to the current standard of care. For these reasons, the scientific community is looking for new chemoth

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… Bioactivities of microorganism extracts/compounds against prostate cancer cells have been reported for marine fungi, bacteria, cyanobacteria and microalgae ( Table 2 ). 3.1. … Cyanobacteria The marine cyanobacterium Lyngbya majuscule , collected from Papua New Guinea, produces aurilides B and C. Both compounds were tested on various cancer cell lines, and aurilide B exhibited high cytotoxicity (with GI50 less than 10 nM) against prostate cancer cells [ 54 ]. …

Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus.

Presynaptic nicotinic acetylcholine receptors (nAChRs) are present in many regions of the brain and potentially serve as targets for the pharmacological action of nicotine in vivo. To investigate their mechanism of action, we performed patch-clamp recordings in relay neurons from slices of thalamus sensory nuclei. In these nuclei, nAChR activation facilitated the release of the inhibitory neurotransmitter GABA. Micromolar concentrations of nicotinic agonists increased the frequency of miniature GABAergic synaptic currents and decreased the failure rate of evoked synaptic currents. These action

Marine Natural Products as Potent Anticancer Agents (2020-2024): Structural Diversity, SARs and Target Prediction.

In recent years, Marine Natural Products (MNPs) have emerged as a significant source for anticancer drug discovery, as many natural products can offer structural diversity, unique mechanisms of action, and relatively low toxicity. This article provides a systematic review of MNPs with reported anticancer activities from 2020 to 2024. These compounds are classified into seven major categories: terpenoids, alkaloids, sterols, polyketides, peptides and proteins, polysaccharides, and macrolides. For each category, we elaborate on the marine sources, structural identification, in vitro anticancer a

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… The marine ecosystem harbors a wealth of biological resources, including corals, sponges, cyanobacteria, algae, and various invertebrates, all of which serve as valuable sources of bioactive MNPs [ 11 ]. … Major sources are marine cyanobacteria (Hormoscilla, Moorea), sponges (Chondrosia), and mollusks (Arca inflata). …

Phytochemical-Based Nanomedicine for Advanced Cancer Theranostics: Perspectives on Clinical Trials to Clinical Use.

In the current chapter, a new strategic compilation of phytochemicals with potent antitumor properties has been addressed, most importantly focusing on cell cycle arrest and apoptotic signaling mechanism. A promising approach in tumor prevention is to eliminate cancer cells preferably via cell cycle arrest and programmed cell death with lesser harm to neighboring normal cells. Cancer cells have a survival advantage to escape apoptosis and relentlessly divide to proliferate, gearing up the cell cycle process. Recently, the use of phytochemical-derived conjugated chemotherapeutic agents has incr

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… NCT02554344 R-(-)-Gossypol acetic acid Gossypium herbaceum (Malvaceae) C 32 H 34 O 10 578.6 g/mol [ 39 ] NCT00773955 NCT00397293 NCT00666666 Beta-lapachone [ARQ 501] Tabebuia avellanedae (Bignoniaceae) C 15 H 14 O 3 242.2 g/mol [ 40 ] NCT00524524 NCT00099190 NCT00358930 Cryptophycins 52 [ LY355703 ] Cyanobacteria … Cryptophycins 52 [ LY355703 ] Cryptophycins 52, is a cytotoxin, initially isolated from blue algae called cyanobacteria (Nostoc sp. ATCC 53,789, Nostoc sp. GSV 224) of Nostocaceae family, a potent microtubule inhibitor, with potential antineoplastic properties. …

Microorganisms Associated with the Marine Sponge Scopalina hapalia: A Reservoir of Bioactive Molecules to Slow Down the Aging Process.

Aging research aims at developing therapies that delay normal aging processes and some related pathologies. Recently, many compounds and extracts from natural products have been shown to slow aging and/or extend lifespan. Marine sponges and their associated microorganisms have been found to produce a wide variety of bioactive secondary metabolites; however, those from the Southwest of the Indian Ocean are much less studied, especially regarding anti-aging activities. In this study, the microbial diversity of the marine sponge Scopalina hapalia was investigated by metagenomic analysis. Twenty-s

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… In our study, the Scopalina hapalia community was dominated by Proteobacteria (62.58%, 94.03% and 57.21% relative abundance in V1–V3, V3–V4 and V4–V5 data sets), Cyanobacteria (16.77%, 0.05% and 11.08%), Planctomycetes (11.71%, 0.06% and 9.90%), Bacteroidetes (4.77%, 1.24% and 17.99%) and Actinobacteria … Previous studies based on 16S rRNA gene sequencing or metagenomic analysis revealed that the prokaryotic microbiome of Scopalina is dominated by Proteobacteria ( Gammaproteobacteria and Betaproteobacteria ) and Cyanobacteria [ 65 , 67 , 68 , 69 ]. …

Algae-Derived Bioactive Compounds as Platforms for Translational Biotechnology and Health Applications.

Marine macroalgae, microalgae, and associated microorganisms are increasingly recognised as valuable sources of bioactive compounds with applications across biotechnology and health. The environmental and ecological conditions they inhabit shape their metabolite diversity, leading to the production of high-value compounds such as sulphated polysaccharides, lipids, pigments, phenolics, and peptides. These compounds exhibit conserved biological activities that underpin potent antioxidant, anti-inflammatory, cytotoxic, and pro-regenerative effects with strong potential for translation. Although e

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… Marine biodiscovery efforts are increasingly focused on microorganisms and primary producers—particularly microalgae (including cyanobacteria), macroalgae (seaweeds), marine bacteria and fungi. … Cryptophycin analogues from cyanobacteria bind tubulin with picomolar affinity, producing catastrophic spindle failure and apoptotic collapse [ 201 ]. …

Кишечная флора связана с риском возникновения хронических неинфекционных заболеваний.

КИСЛОТА: Кишечная флора (IF) связана с риском неинфекционных заболеваний, особенно различных видов рака, инсульта и болезни Альцгеймера. Однако на различных этапах роста, развития и старения все еще существует много неопределенностей в отношении этих ассоциаций. Поэтому необходимы дальнейшие углубленные исследования. AIM: Изучение связей человека с риском заболевания на различных этапах роста, развития и старения в целях получения более точных и убедительных выводов.МЕТОДЫ: Коорт, кросс-секции, контроль за конкретными случаями и исследования по случайной менделии, опубликованные в базах данных

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… Bacteria are relatively the most suitable microorganisms for growth in the intestinal microenvironment, accounting for up to 90% of the IF, among which Firmicutes , Bacteroidetes , Actinobacteria , Clostridium , Proteobacteria , Verrucobacteria , and Cyanobacteria are typically the seven most …

Anticancer natural products from the Middle East and North Africa: biodiversity, mechanisms, and translational challenges.

Cancer remains one of the leading causes of morbidity and mortality worldwide, imposing substantial clinical, societal, and economic burdens. Despite major advances in surgical oncology, systemic chemotherapy, radiation therapy, molecularly targeted therapeutics, and immune checkpoint inhibition, contemporary cancer treatment remains constrained by dose-limiting toxicities, intratumoral and intertumoral heterogeneity, and the inexorable emergence of multifaceted drug resistance mechanisms. These persistent therapeutic challenges have reinstated interest in natural products (NPs) as evolutionar

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… Psammaplins, including Psammaplin A and its dimer bisaprin, were initially isolated from verongid sponges ( Psammaplysilla sp.) but later confirmed to originate from associated cyanobacteria and heterotrophic bacteria. … Marine sponges and cyanobacteria from the region contribute a structurally diverse repertoire of bioactive metabolites, like actinosporins and lyngbyatoxins, with documented cytotoxic and signaling modulatory activities ( 219 ). …

Transcriptional analysis of BMP2 and BMP6 in patients with newly diagnosed multiple myeloma.

Multiple myeloma (MM) is a highly heterogenous disease with diverse outcomes across patients. Stratifying patients is a promising approach to predict their clinical outcomes. However, despite notable progress in stratification systems, there is still a need for further optimization. Combining the existing staging parameters with molecular approaches could offer a better understanding of 'high risk' disease and guide treatment decisions. Bone morphogenetic proteins (BMPs) represent a group of proteins, which are members of the TGF-β superfamily that are now considered to be multifunctional cyto

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… Okamoto T Okabe S Ultraviolet absorbance at 260 and 280 nm in RNA measurement is dependent on measurement solution Int J Mol Med 5 657 659 2000 10812018 10.3892/ijmm.5.6.657 18 Pinto FL Thapper A Sontheim W Lindblad P Analysis of current and alternative phenol based RNA extraction methodologies for cyanobacteria …

Biomaterials from the sea: Future building blocks for biomedical applications.

Marine resources have tremendous potential for developing high-value biomaterials. The last decade has seen an increasing number of biomaterials that originate from marine organisms. This field is rapidly evolving. Marine biomaterials experience several periods of discovery and development ranging from coralline bone graft to polysaccharide-based biomaterials. The latter are represented by chitin and chitosan, marine-derived collagen, and composites of different organisms of marine origin. The diversity of marine natural products, their properties and applications are discussed thoroughly in t

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… Many MMAs have been identified from red algae, sea stars, corals, dinoflagellates and cyanobacteria after the initial discovery of the mycosporines porphyra-334 and shinorine. Porphya-334 and shinorine are potent monoamine oxidase inhibitors. … They are present in high concentrations in Aphanizomenon flos-aquae (a species of cyanobacteria) and Klamath blue-green microalgae [ 203 ]. …

Гут микробиота и ее влияние на ось Гут-Брэйна в сравнении с пациентами, страдающими химиотерапией, и данными о безраковых методах контроля в вычислительной перспективе рака груди.

Рак груди (БК) по-прежнему является одной из основных причин связанных с раком заболеваний и смертности среди женщин во всем мире. Традиционное лечение включает хирургию, радиацию, гормональную терапию и химиотерапию, но эти методы часто сталкиваются с трудностями из - за изменчивости реакции пациента и неблагоприятных последствий. В рамках этого исследования изучалась взаимосвязь между разнообразием кишечного микробиома, составом общины и анализом путей развития у женщин, проходящих химиотерапию в Британской Колумбии (Время лечения - DT), по сравнению с мерами по борьбе с раком (КФК). Использ

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… PDZRN3 4 2 0.264 0.0231 Finegoldia; Peptoniphilus; Coprococcus; Comamonadaceae; Moraxella Peptoniphilus; Coprococcus; FAM134A 5 2 0.33 0.0369 Prevotellaceae; Bacillus; Clostridiales; Moryella; Veillonella Bacillus;Veillonella MAP1S 5 2 0.33 0.0369 Porphyromonadaceae; Cyanobacteria …

Влияние ПГПР на структуру микробиологической сообщества ризосферы и урожайность солончаковых зерновых культур.

Растворяющиеся в почве бактерии, способствующие росту растений (PGPR), могут защищать растения от почвенных заболеваний и абиотических стрессовых условий. Основная цель данного исследования заключалась в оценке влияния различных PGPR (TF1, TF2, TF3 и TF4) на микробную сообщество ризосферы зерна для корма в солончаково-щелочной поле с использованием высокопроизводительной технологии последовательного секвенирования Illumina MiSeq. Результаты показали, что различные PGPRs значительно увеличили плотность уборки (на 21,31–45,16%), высоту растения (на 9,12–19,98%), диаметр стебля (на 30,07–45,78%)

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… Phylum Level At the phylum level, the study of bacterial communities in saline–alkaline soils revealed that the dominant phyla across different treatments were Actinobacteriota, Proteobacteria, Chloroflexi, Acidobacteriota, Gemmatimonadota, Bacteroidota, Myxococcota, Firmicutes, Verrucomicrobiota, and Cyanobacteria …

Биоинформатический анализ взаимодействия миелинов и микробов говорит о том, что в патогенезе множественных склерозов присутствуют различные виды молекулярной имитации.

Множественный склероз (MS) — разрушительная аутоиммунная болезнь, приводящая к разрушению милиновой оболочки в центральной нервной системе человека (КНС). Было установлено, что инфекция вирусов и бактерий тесно связана с наступлением мороза или его остротой. Мы предположили, что атака иммунной системы на милиновую оболочку может быть спровоцирована вирусами и бактериальными антигенами, которые напоминают компоненты миелиновой оболочки. Для выявления вирусных и бактериальных антигенов, похожих на миелин олигодендроцит гликпротеин (МОГ) и миелинский основной протеин (МБП), был применен подход, о

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… The analysis also identified an NAD(P)H-quinone oxidoreductase enzyme from two cyanobacteria, the freshwater single-celled cyanobacterium Synechocystis sp. PCC6803 [ 66 ] and Thermosynechococcus elongatus . …