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Prehabilitation for Pressure Ulcer Surgery: A Practical and Evidence-based Guide.

BACKGROUND: The objective of this study is to synthesize current evidence and provide a clinically actionable framework for perioperative pr … ograms, delivered through physical therapy, enhanced functional reserve. Among ambulatory patients, metabolic equivalent levels less than 4 identified higher perioperative risk, with prehabilitation notably improving functional capacity. CONCLUSIONS: Multidisciplinary, evidence-based prehabilitation targeting modifiable risk factors improves physiological readiness a …

Сочетание физического объема и риска заболеваний нервной системы: ретроспективное когортное исследование.

ОКРУЖАЮЩАЯ СРЕДА: Объем физической активности (ПАВ) связан с широким спектром последствий для здоровья; однако его связь с случайными заболеваниями нервной системы по-прежнему не до конца изучена. В этом исследовании были изучены их взаимоотношения с использованием данных из UK Biobank. МЕТОДЫ: Было проведено ретроспективное когортное исследование, охватывающее 278,306 - участники из Биобанка Соединенного Королевства. ПАВ была определена как метаболический эквивалент задач (МЕТ) минут в неделю на основе саморегистрируемых уровней физической активности и классифицирована по категориям: three гр

Совпадение в аннотации оригинала
BACKGROUND: Physical activity volume (PAV) has been linked to a wide range of health outcomes; however, its association with incident nervou … ohort study was conducted involving 278,306 participants from the UK Biobank. PAV was quantified as metabolic equivalent of task (MET) minutes per week, derived from self-reported physical activity levels, and categorized into three groups. Incident cases of nervous system diseases were identified through ICD-10 codes obtained from hospital inpatient records, death re …

Does timing of physical exercise after reconstructive prolapse surgery matter?

BACKGROUND: Pelvic organ prolapse (POP) affects many women and impacts quality of life. Evidence on physical activity in this population is … apse stage: stage II (n = 137) and stage III-IV (n = 329). Physical activity was measured using the metabolic equivalent task (MET). Secondary outcomes included the Pelvic Floor Distress Inventory (PFDI) and the Pelvic Floor Impact Questionnaire (PFIQ). The mixed model was used to analyze the MET, POP symptoms, and QoL at baseline, 3 months, and 12 months after surger …

Migraine attack prediction using wearable biosensor data.

BackgroundMany migraine sufferers report difficulties in managing their attacks, leading to missed workdays, impaired cognitive function and … (Empatica Inc., Boston, MA, USA) capturing electrodermal activity, heart rate, skin temperature and metabolic equivalent of task were analysed using machine learning models to detect prodromal autonomic nervous system alterations and predict impending migraine headaches. Personalised models were developed using participant-specific model selection, whereas generalised …

Domain-specific physical activity and its association with depression severity in older Korean adults: insights from the 2022 Korea national health and nutrition examination survey.

PURPOSE: Depression is a growing mental health issue among older adults in South Korea, where rapid population aging has intensified the nee … sessed using Patient Health Questionnaire-9 (PHQ-9). Physical activity levels were quantified using metabolic equivalent (MET-minute) thresholds. Data were statistically analyzed using descriptive statistics, chi-square tests, and ordinal logistic regression. RESULTS: Of the participants, 85.27% reported no depression, while 14.73% experienced mild to severe symptoms …

Cardiorespiratory Fitness Prediction in Vestibular Hypofunction: Does One Size Fit All?

Cardiorespiratory fitness is a strong predictor of health and mortality. However, its gold-standard assessment, peak oxygen uptake via cardi … sestimated cardiorespiratory fitness (effect size=0.56-0.68, large). Predictions within one or more metabolic equivalent of task were higher for vestibular hypofunction models, reaching up to 8-9 out of 10 individual cases. The newly developed vestibular hypofunction-specific models offer more accurate, clinically applicable tools for cardiorespiratory fitness estimat …

Impact of Physical Activity on Smoking, Sleep Disorders, and Depression Among U.S. Adults.

Smoking negatively impacts lung function and cardiovascular capacity, making physical activity (PA) more challenging and contributing to mental health issues. This study investigates the role of PA in mitigating the links between smoking, sleep disorders, and depressive symptoms in adults in the United States. Data from the 2017 to 2020 National Health and Nutrition Examination Survey (NHANES) were examined. Participants were categorized by PA adherence (≥ 900 metabolic equivalent tasks [METs]/week or not) and smoking status based on serum cotinine levels (< 0.05 for non-smokers, 0.05-15 for s…

Physical activity and lower extremity lymphedema among endometrial cancer survivors: A population-based cross-sectional study.

OBJECTIVE: The aims of this cross-sectional study were to describe the prevalence of self-reported lower extremity lymphedema (LEL) by diffe … ty Frequency, Intensity, and Duration (PAFID) questionnaire. Responses of PAFID were converted into metabolic equivalent of task minutes per week (MET-min/week), and participants were categorized into different PA levels: meeting (≥500 MET-min/week) versus not meeting PA guidelines; low active (<500 MET-min/week), active (500-1000 MET-min/week), and high active (>1000 …

Physical activity, frailty, and kinesiophobia among older adult patients with coronary heart disease in China.

BACKGROUND: Physical activity (PA) offers advantages in the secondary prevention of coronary heart disease (CHD). However, in older adults, … ailty were 20.5 % and 46.4 %, respectively. The mean kinesiophobia score was 43.13±5.48. The median metabolic equivalent of task of PA was 2784 MET-min/week, and 25.1 % of the patients did not reach the minimum recommended by AHA (150 mins/week). Spearman rank correlation analysis showed that PA was negatively correlated with frailty (r = -0.559, P < 0.001) and kinesi …

Coronary artery calcium in athletes: friend or foe?

Regular physical activity and high cardiorespiratory fitness protect against cardiovascular disease-related morbidity and mortality and all- … that engaging in moderate-to-vigorous physical activity, exceeding approximately five hours or 2000 Metabolic Equivalent of Task-mins per week, is associated with increased prevalence and progression of coronary artery calcium and coronary plaques in males. This relationship appears intensity-dependent, with higher-intensity physical activity linked to greater progres …

Assessing the ecotoxicity of wastewater effluents contaminated with illicit drugs and benzodiazepines: Insights from ZFL cell exposure.

Ecotoxicity of wastewater effluent contaminated with illicit drugs and benzodiazepines was evaluated by utilizing Zebrafish Liver cells (ZFL) as a streamlined and economical model for efficiently assessing aquatic toxicity, compared to other tiers such as Effect Directed Analysis (EDA). Rather than applying EDA, which aims to identify causative toxicants, this study provides a complementary line of evidence by directly assessing the cumulative biological effects of the complex mixture using in vitro bioassays. Detection and quantification of illicit drugs and benzodiazepines, even at trace lev

Ventilatory inefficiency limits 6-min walked distance in systemic sclerosis-associated interstitial lung disease.

Systemic sclerosis-associated interstitial lung disease (SSc-ILD) impacts cardiopulmonary systems and exercise capacity serves as a marker of disease severity. While the six-minute walking test (6MWT) is widely used to assess physical performance, its limitations to assess the cardiopulmonary function remain unresolved in SSc-ILD patients. This study aimed to investigate cardiorespiratory adaptations during the 6MWT, hypothesizing that ventilatory inefficiency is related to exercise capacity in SSc-ILD patients. We recruited 23 female SSc-ILD patients and 13 age- and sex-matched healthy contro

Dietary intake, obesity, and physical activity in association with biliary tract cancer risk: Results from meta-analyses of individual-level data from prospective cohort studies of 723,326 adults.

Biliary tract cancer (BTC) is a rare and aggressive malignancy with increasing incidence. Most BTC cases are diagnosed with metastatic disea … omparing BMI-adjusted WHR top to bottom quartile: 1.20 (0.94, 1.53), p-trend = .05; comparing ≥15-0 metabolic equivalent task-hours/week 0.76 (0.61, 0.94), p-trend = .009; comparing highest to lowest intake tertile for fruit and fish 0.79 (0.66, 0.95), p-trend = .01; 0.82 (0.68, 0.98), p-trend = .04, respectively. Associations were, in general, similar across ancestry …

Effects of 5-Week Oral Acetazolamide on Incremental Cycling Exercise in Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension: A Randomized Placebo-Controlled, Double-Blinded, Crossover Trial.

INTRODUCTION: Acetazolamide (AZA) improves nocturnal and daytime blood oxygenation in patients with pulmonary vascular disease (PVD), defined as pulmonary arterial and distal chronic thromboembolic pulmonary hypertension (CTEPH), and may improve exercise performance. METHODS: We investigated the effect of 5 weeks of AZA (250 mg bid) versus placebo on maximal load during incremental cycling ramp exercise in patients with PVD studied in a randomized controlled, double-blind, crossover design, separated by &gt; 2 weeks of washout. RESULTS: Twenty-five patients (12 pulmonary arterial hypertensio

Left Ventricular Longitudinal Strain Abnormalities in Childhood Exposure to Anthracycline Chemotherapy.

Current mortality is low in cases of childhood acute leukemia. Dilated cardiomyopathy induced by anthracyclines remains the main cause of mo … luded. The physical activity performed by the patients before and after treatment was quantified in metabolic equivalent tasks, MET.h, per week. An echocardiographic assessment was performed, including strain analysis. Thirty-eight patients with a median age of 5 [3-8] years were included. Dilated cardiomyopathy was diagnosed in 3 patients and longitudinal strain abno …

Establishing how much improvement in lung function and distance walked is clinically important for adult patients with Pompe disease.

BACKGROUND AND PURPOSE: Pompe disease is a rare, inheritable, progressive metabolic myopathy. This study aimed to estimate the minimal clinically important difference (MCID) for an improvement in forced vital capacity in the upright seated position (FVCup) and the 6-min walk test (6MWT) after a year of treatment with enzyme replacement therapy. METHODS: Data were obtained from two prospective follow-up studies. Between-group and within-group MCIDs were estimated using anchor-based methods. Additionally, a distribution-based method was used to generate supportive evidence. As anchors, self-rep

Effects of systematic cardiac rehabilitation training in elderly patients with unstable angina following cardiac stent implantation.

BACKGROUND: Coronary stent implantation is usually used to treat unstable angina to alleviate stenosis or occlusion, promoting blood flow re … wo groups. RESULTS: After intervention, the rehabilitation group observed greater VO2 Max, maximum metabolic equivalent, eft ventricular ejection fraction, left ventricular end-diastolic diameter and smaller left ventricular end-systolic diameter. And the rehabilitation group observed greater scores of physical activity limitation, stable angina pectoris, treatment s …

Examining Risk Factors Related to Cardiac Rehabilitation Cessation Among Patients With Advanced Heart Failure.

PURPOSE: Cardiac rehabilitation (CR) is beneficial in heart transplant and left ventricular assist device (LVAD) recipients, but patterns of … logistic and linear regressions. Among participants with complete adherence, we compared changes in metabolic equivalent of task (MET), exercise time, and peak oxygen uptake using paired sample t tests. RESULTS: There were 137 heart transplant and LVAD recipients (median age 56.9 years, 74% male) who attended CR. Among them, 91% either completed 36 CR sessions or <24 …

Chemical exploration of different extracts from Phytolacca americana leaves and their potential utilization for global health problems: in silico and network pharmacology validation.

Phytolacca americana L. is of great interest as a traditional additive in various folk remedies in several countries, including Turkey. We aimed to determine the chemical profile (assisted by high-Performance liquid chromatography-electrospray ionization-tandem mass apectrometry (HPLC-ESI-MS/MS) experiments of three extracts obtained by different polarity solvents viz. ethyl acetate (to extract semipolar compounds), methanol and water (to extract highly polar metabolites) from P. americana leaves. Their anti-diabetic effects were investigated in vitro by assessing their inhibition toα-amylase

Changes in physical activity during the year after the Great East Japan Earthquake and future frailty in older survivors.

AIM: This study examines whether changes in physical activity (PA) during the first year after the Great East Japan Earthquake and Tsunami (2011-2012) contributed to preventing the onset of future frailty among older survivors of the disaster. METHODS: This study tracked 2561 physically active Japanese survivors aged ≥ 65 years (43.6% men; mean age 72.9 years) who had completed self-administered questionnaires in 2011 and 2012. PA levels for participants were classified into four categories based on ≥23 and <23 metabolic equivalent hours/week in 2011 and 2012: "consistently low," "decreasing,…