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WEBINO Syndrome Secondary to Multiple Sclerosis Treated Surgically.

WEBINO syndrome (wall-eyed bilateral internuclear ophthalmoplegia) is a rare neuro-ophthalmological disorder characterized by bilateral adduction deficit, abducting nystagmus, large-angle exotropia in the primary gaze position, and impaired convergence, secondary to bilateral lesion of the medial longitudinal fasciculus. We report the case of a 35-year-old woman with multiple sclerosis who consulted for persistent horizontal binocular diplopia. Examination revealed alternating exotropia of 50 prism diopters with bilateral adduction limitation, abducting nystagmus, and absence of convergence, c…

Cortical Lesions Form Predominantly in Early Multiple Sclerosis.

BACKGROUND AND OBJECTIVES: Cortical lesions are common in multiple sclerosis (MS) and associated with disability, but their characterization in early MS has been limited. Here, we aimed to characterize cortical lesions in newly diagnosed MS with 7 tesla (T) brain MRI. METHODS: Adults within 14 months of relapsing-remitting MS diagnosis underwent 7T brain MRI and clinical evaluation at Mount Sinai. Cortical lesions were identified using T1-weighted (w) (median of three acquisitions) and T2*w images (both at 0.5mm3). Non-cortical brain lesions were segmented on 0.7mm3 T1w images. Lesion burden …

Diurnal step count patterns in progressive multiple sclerosis.

BACKGROUND: Progressive multiple sclerosis (MS) leads to increasing disability, commonly assessed using the Expanded Disability Status Scale (EDSS) and the Timed 25-Foot Walk (T25FW). However, these episodically assessed, in-clinic measures miss diurnal fluctuations in mobility. OBJECTIVE: To evaluate whether diurnal step count patterns reflect MS-related disability and whether these associations persist after accounting for temporal context and Kurtzke Functional Systems Scores (KFS). METHODS: Minute-level step count data were collected from 529 progressive MS patients over 27 months in the…

Повторение множественных склерозов с помощью клеточной терапии CAR-T.

Множественный склероз (MS) — хроническое аутоиммунное расстройство центральной нервной системы, характеризующееся аберрантной иммунной реакцией на миелин и нейрональные антигены, приводящее к обезвоживанию, аксоновой травме и прогрессивному неврологическому расстройству. Несмотря на то, что нынешняя иммунодуляторная терапия может уменьшить частоту рецидивов и медленные темпы развития заболеваний, она редко вызывает долговременную ремиссию или обратно установившуюся патологию. В качестве перспективной стратегии лечения аутоиммунных заболеваний недавно была разработана клеточная терапия химерног

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system characterized by aberrant immune responses against myelin and neuronal antigens, resulting in demyelination, axonal injury, and progressive neurological impairment. Although current immunomodulatory therapies can reduce relapse frequency and slow disease progression, they …

Subventricular Zone Microstructure in Pediatric-Onset Multiple Sclerosis.

OBJECTIVE: The aim of this study was to explore the microstructural dynamics of the subventricular zone (SVZ) with aging and their associations with clinical disability and brain structural damage in pediatric-onset multiple sclerosis (MS) patients. METHODS: One-hundred and forty-one pediatric-onset MS patients (67 pediatric and 74 adults with pediatric-onset) and 233 healthy controls (HC) underwent neurological and 3.0 T MRI assessment. Fractional anisotropy (FA) and mean diffusivity (MD) were extracted from the SVZ and the thalamus (as control region). RESULTS: In HC, SVZ FA was higher unt…

Мониторинг множественных склерозов: цифровые и жидкие биомаркеры фаз.

ЦЕЛЬ ОБЗОРА: В настоящее время мониторинг активности заболеваний и реакции на лечение при множественном склерозе (МС) основывается на интеграции качественных клинических и радиологических данных, которые имеют ограниченную ценность с точки зрения прогнозирования. Ожидается, что целый ряд количественных цифровых и жидких биомаркеров, многие из которых находятся на грани широкого клинического перевода, ознаменуют собой новую эру терапевтической стратегии, основанной на данных, особенно в том, что касается последовательности методов лечения, направленных на изменение болезней (ДМТ). Имеющиеся выс

Совпадение в аннотации оригинала
PURPOSE OF REVIEW: Monitoring of disease activity and treatment response in multiple sclerosis (MS) currently relies on the integration of qualitative clinical and radiological data that is of limited predictive value. An array of quantitative digital and fluid biomarkers, many on the cusp of broad clinical translation, is expected to herald a new era of dat…

Спинал Корд Аномалии в раннем педиатрии Множественный Склероз.

Повреждения спинного мозга и атрофия в шейной области широко распространены во взрослом множестве склероза (MS) и коррелируют с инвалидностью. О том, происходят ли аналогичные аномалии у пациентов педиатрической системы MS, практически ничего не известно. Клинические и МРТ-оценки были проведены у 38 пациентов педиатрии MS и 13 здоровых методов контроля (HC). Никаких существенных различий между пациентами, страдающими синдромом MS и HC, и пациентами, страдающими от повреждений и без них, выявлено не было. Пациенты, страдающие повреждениями, продемонстрировали повышенный объем пуповины, которая

Совпадение в аннотации оригинала
Spinal cord lesions and atrophy in the cervical region are common in adult multiple sclerosis (MS) and correlate with disability. Whether similar abnormalities occur in pediatric MS patients is largely unknown. Clinical and MRI evaluations were performed in 38 pediatric MS patients and 13 healthy controls (HC). No significant differences in upper cervical co…

Clinical characteristics associated with multiple sclerosis fatigue severity.

BACKGROUND: While clinical factors such as higher Expanded Disability Status Scale (EDSS) score, progressive disease subtype, older age, polysymptomatic onset, and depression have been shown to predict fatigue severity in people with multiple sclerosis (PwMS), their influences have not been evaluated simultaneously while controlling for broader MS severity risk factors and potential confounders. OBJECTIVE: To concurrently assess which previously established MS fatigue risk factors affect fatigue severity after adjusting for MS severity, obstructive sleep apnea (OSA), and stimulant use, and to…

Early Disease-Modifying Treatments for Presymptomatic Multiple Sclerosis.

Radiologically isolated syndrome (RIS) is the earliest stage in the disease continuum of multiple sclerosis (MS). RIS is discovered incidentally in individuals who are asymptomatic but have typical lesions in the brain and/or spinal cord suggestive of demyelination. The 2009 and revised 2023 RIS criteria were developed for diagnosis. Presymptomatic individuals who fulfill the 2009 RIS criteria by having 3-4 of 4 dissemination in space McDonald 2005 MS criteria are still diagnosed with RIS using the revised 2023 RIS criteria. In presymptomatic individuals who do not fulfill the 2009 RIS criteri…

Priority setting: women's health topics in multiple sclerosis.

BACKGROUND: A scoping review found that most studies on women's health in multiple sclerosis (MS) focused on pregnancy, fetal/neonatal outcomes and sexual dysfunction. Few studies addressed menopause, contraception, gynecologic cancers/cancer screening. However, the perceived relative importance of these knowledge gaps to people living with MS and other partners is unknown. We engaged a range of partners, including people living with MS, health care providers, researchers, and patient advocacy groups, to set priorities for future research in women's health in MS. METHODS: We employed a three-…

Consultative, Proactive Physical Therapy in Early Multiple Sclerosis.

BACKGROUND: Exercise training may be the most effective nonpharmacological symptomatic treatment for patients with multiple sclerosis (MS). Physical therapy (PT) can facilitate increased exercise through education, individualized exercise routines, goal setting, and supportive resources. However, traditional PT focuses on function restoration rather than proactive measures to prevent the advancement of morbidity. We present the application of a proactive physical therapy (PAPT) approach for individuals with MS. METHODS: Neurologists referred patients to PT shortly after their MS diagnosis. Pa…